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首页> 外文期刊>Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry >Preparation of oxygenated apatite from hydrolysis of cured brushite cement in aqueous medium
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Preparation of oxygenated apatite from hydrolysis of cured brushite cement in aqueous medium

机译：在水介质中水解固化透钙磷石水泥制备含氧磷灰石

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Several approaches have been developed for the preparation of calcium phosphate cements, some of them are commercially available, and they have proved very effective bone substitutes in different applications. Some of their properties, such as the ability to incorporate different molecules make them very interesting candidates as drug carriers. We were interested in this paper to the study of the hydrolysis after curing a cement composed of the tricalcium phosphate (-TCP) and monocalcium phosphate monohydrate (MCPM), in aqueous solution with a controlled pH, leading system to transform towards other calcium phosphates known by their very wide including biological and medical applications. In this study the operating conditions are chosen in order to have apatite containing molecular oxygen. Characterization by analyzes (IR, XRD etc.) show that the proposed process provides better results for oxygenated apatite containing together molecular oxygen and peroxide ions. These are removed by heating the final product at a temperature of 300 ° C.
机译：已经开发了几种制备磷酸钙水泥的方法，其中一些是可商购的，并且已证明它们在不同应用中非常有效的骨替代物。它们的某些特性，例如掺入不同分子的能力，使其成为非常有趣的候选药物载体。我们对本文感兴趣的是在pH受控的水溶液中固化由磷酸三钙（-TCP）和磷酸一水合一水合物（MCPM）组成的水泥后水解的研究，从而导致系统转化为其他已知的磷酸钙其广泛的应用范围包括生物学和医学应用。在这项研究中，选择操作条件以使磷灰石含有分子氧。通过分析（IR，XRD等）表征表明，所提出的方法为同时包含分子氧和过氧化物离子的氧化磷灰石提供了更好的结果。通过在300°C的温度下加热最终产品将其除去。

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