Studies in the synthesis and applications of 4-(aminomethyl)quinolin-2(1H)-=one derivatives as anti-cancer agents.

Radhika Sharma; Shubhangi S. Soman; Shweta V. Patel; Ranjitsinh V. Devkar

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Studies in the synthesis and applications of 4-(aminomethyl)quinolin-2(1H)-=one derivatives as anti-cancer agents.

机译：4-（氨基甲基）喹啉-2（1H）-＝一种衍生物作为抗癌剂的合成与应用研究。

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2-quinolone derivatives find applications as antimicrobial, anti-viral and anticancer agents. 3-Aryl and N-methyl derivatives of 2-quinolone have been reported as most potent anti-cancer agents. Present study involves synthesis, characterization of novel4-(aminomethyl)quinolin-2(1H)-onederivatives, 7a-e, devoid of 3-aryl and N-methyl substitutions and their application as anti-cancer agents. MTT assay of the synthesized new chemical entities against A549 cell line was carried out and compound 7e was found to be the most potent anti-cancer agent in the series.

机译：2-喹诺酮衍生物作为抗微生物剂，抗病毒剂和抗癌剂得到应用。据报道2-喹诺酮的3-芳基和N-甲基衍生物是最有效的抗癌药。目前的研究涉及合成，表征新型4-（氨基甲基）喹啉-2（1H）-一衍生物7a-e，没有3-芳基和N-甲基取代及其作为抗癌剂的应用。进行了针对A549细胞系的合成新化学实体的MTT分析，发现化合物7e是该系列中最有效的抗癌剂。

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《Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry》 |2014年第5期|共7页
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Radhika Sharma; Shubhangi S. Soman; Shweta V. Patel; Ranjitsinh V. Devkar;
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机译：合成4-（氨基甲基）喹啉-2（1H） - 酮

Studies in the synthesis and applications of 4-(aminomethyl)quinolin-2(1H)-=one derivatives as anti-cancer agents.

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