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首页> 外文期刊>Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry >Synthesis and anti-tumor evaluation of novel organoselenocyanates and symmetrical diselenides dyestuffs
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Synthesis and anti-tumor evaluation of novel organoselenocyanates and symmetrical diselenides dyestuffs

机译：新型有机硒酸酯和对称二硒化物染料的合成及抗肿瘤评价

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A convenient procedure for the synthesis of novel organoselenium compounds was developed from simple aniline selenocyanate 1 and its corresponding diselenide 2. Their chemical reactivity was investigated towards azo coupling type reactions and their corresponding diazo derivatives 3a,b and 5a,b were sequentially obtained. Besides, heterocyclic selenocyanates 7-9 and diselenocyanate 10 were obtained by the subsequent reaction of hydrazines diazo 3a,b and 5b compounds, respectively. Furthermore, condensation of 1 and 2 with phthalic anhydride afforded the phthalimide selenocyanates 4a,b and 6, alternately. Moreover, some representatives of the new synthesized compounds were evaluated for their antitumor activity and were found to be more cytotoxic compared to their corresponding analogues without selenium. It is worth mentioning that the dying characteristic of these compounds was also evaluated and found to exhibit good dying properties.
机译：从简单的苯胺硒氰酸酯1及其相应的二硒化物2开发了一种方便的合成新型有机硒化合物的方法。研究了它们对偶氮偶合型反应的化学反应性，并依次获得了其相应的重氮衍生物3a，b和5a，b。此外，通过肼重氮3a，b和5b化合物的后续反应分别获得杂环硒代氰酸酯7-9和二硒代氰酸酯10。此外，将1和2与邻苯二甲酸酐缩合，交替得到邻苯二甲酰亚胺亚硒酸酯4a，b和6。此外，评估了新合成化合物的一些代表的抗肿瘤活性，并发现它们与不含硒的相应类似物相比具有更高的细胞毒性。值得一提的是，还评估了这些化合物的染色特性，发现它们具有良好的染色特性。

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