Microwave Assisted One Pot Synthesis of 2, 3-Di-Substituted Quinazolin-4-(3h)-Ones and Their Potential Biological Activity

Akhil A. Nagar; Dr. L. G. Rathi; Dr. Naresh Chugh; Vilas J. Pise; Atul Bendale

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Microwave Assisted One Pot Synthesis of 2, 3-Di-Substituted Quinazolin-4-(3h)-Ones and Their Potential Biological Activity

机译：微波辅助一锅合成2，3-二取代的喹唑啉-4-（3h）-一及其潜在的生物活性

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The 2, 3-di-substituted quinazolin-4-(3H)-ones (III) have been synthesized as a one pot procedure from the reaction of Anthranilic acid (I), acid chlorides and primary amines with the intermediate 4-(3H)-benzoxazinone (II) at different microwave conditions. High yield, less by products, short reaction time (7-10 min), mild conditions and easy work-up are the advantages of this methodology.

机译：通过邻氨基苯甲酸（I），酰氯和伯胺与中间体4-（3H）反应的一锅法合成了2，3-二取代的喹唑啉-4-（3H）-酮（III））-苯并恶嗪酮（II）在不同的微波条件下。该方法的优点是高收率，副产物少，反应时间短（7-10分钟），条件温和且易于后处理。

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《Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry》 |2010年第3期|共7页
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Akhil A. Nagar; Dr. L. G. Rathi; Dr. Naresh Chugh; Vilas J. Pise; Atul Bendale;
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Microwave Assisted One Pot Synthesis of 2, 3-Di-Substituted Quinazolin-4-(3h)-Ones and Their Potential Biological Activity

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