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首页> 外文期刊>Dental Press Journal of Orthodontics >Effect of orthodontic forces on levels of enzymes in gingival crevicular fluid (GCF): A systematic review
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Effect of orthodontic forces on levels of enzymes in gingival crevicular fluid (GCF): A systematic review

机译：正畸力对龈沟液（GCF）中酶水平的影响：系统评价

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Objective: Orthodontic force application releases multiple enzymes in gingival crevicular fluid (GCF) for activation, resorption, reversal, deposition of osseous elements and extracellular matrix degradation. The current systematic review critically evaluated all existing evidence on enzymes in orthodontic tooth movement. Methods: Literature was searched with predetermined search strategy on electronic databases (PubMed, Scopus, Embase), along with hand search. Results: Initial search identified 652 studies, shortlisted to 52 studies based on PRISMA. Quality assessment further led to final inclusion of 48 studies (13 moderately and 35 highly sensitive studies). Primary outcomes are significant upregulation in GCF levels of enzymes-aspartate aminotransferase (AST), alkaline phosphatase (ALP), matrix metalloproteinases (MMPs), lactate dehydrogenase (LDH), β-glucuronidase (βG), tartrate resistant acid phosphatase (TRAP), acid phosphatase (ACP) and down regulation in cathepsin B (Cb). Site specificity is shown by ALP, TRAP, AST, LDH, MMP9 with levels at compression site increasing earlier and in higher quantities compared with tension site. ALP levels are higher at tension site only in retention. A positive correlation of LDH, ALP and AST is also observed with increasing orthodontic force magnitude. Conclusions: A strong evidence of variation in enzymes (ALP, AST, ACP TRAP, LDH, MMPs, Cb) in GCF is found in association with different magnitude, stages and sites of orthodontic force application.
机译：目的：施加正畸力可释放龈沟液（GCF）中的多种酶，以激活，吸收，逆转，骨成分沉积和细胞外基质降解。当前的系统综述对正畸牙齿移动中有关酶的所有现有证据进行了严格评估。方法：通过预定的搜索策略在电子数据库（PubMed，Scopus，Embase）上进行文献搜索，并进行手工搜索。结果：初步搜索确定了652项研究，根据PRISMA入围了52项研究。质量评估进一步导致最终纳入48项研究（13项中度研究和35项高敏感性研究）。主要结局是天冬氨酸转氨酶（AST），碱性磷酸酶（ALP），基质金属蛋白酶（MMP），乳酸脱氢酶（LDH），β-葡萄糖醛酸苷酶（βG），酒石酸盐抗性酸性磷酸酶（TRAP）的GCF水平显着上调，磷酸磷酸酶（ACP）和组织蛋白酶B（Cb）中的下调。 ALP，TRAP，AST，LDH，MMP9显示了位点特异性，与张力位点相比，受压位点的水平增加得更早，数量也更高。仅在保留时，张力部位的ALP水平较高。随着正畸力大小的增加，LDH，ALP和AST也呈正相关。结论：发现与正畸力施加的大小，阶段和部位不同相关的GCF中酶（ALP，AST，ACP TRAP，LDH，MMPs，Cb）变化的有力证据。

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