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Activity of enzymatic antioxidants in periodontitis: A systematic overview of the literature

机译：酶促抗氧化剂在牙周炎中的活性：文献的系统综述

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Periodontitis is initiated by a bacterial infection and an abnormal immune response of the host resulting in the formation of dysbiotic subgingival biofilm and the progressive destruction of the attachment apparatus of the teeth. It is believed that disturbances in the local and/or general indicators of oxidative stress are one of the mechanisms in the etiopathogenesis of periodontitis. Organisms using oxygen in their metabolic processes are equipped with mechanisms that protect against the activity of oxygen-free radicals. They are commonly referred to as ‘the antioxidative barrier of the system’. The main enzymatic antioxidants which have been widely studied in the gingival fluid, saliva and blood serum of patients with periodontitis are superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT). The aim of this systematic overview of the literature was to present the current research on the activity of these antioxidant enzymes in the gingival fluid, saliva and blood serum of patients with periodontitis. Findings on the activity of these enzymes in the gingival tissue, gingival fluid, saliva, and blood serum in the course of the types of periodontitis that have been classified so far (chronic or aggressive) are quite disparate. Their activity in the gingival tissue was usually elevated, whereas in the saliva it was reduced. These differences may have resulted from the different methods of biochemically assessing their activity, and may have not reflected the stage and/or the risk of progression of periodontitis.
机译：牙周炎是由细菌感染和宿主的异常免疫反应引起的，导致形成不良生物的龈下生物膜并逐渐破坏牙齿的附着装置。据信，氧化应激的局部和/或一般指标的紊乱是牙周炎的发病机理中的机制之一。在新陈代谢过程中使用氧气的生物具有防止氧气自由基活动的机制。它们通常被称为“系统的抗氧化屏障”。在牙周炎患者的牙龈液，唾液和血清中广泛研究的主要酶促抗氧化剂是超氧化物歧化酶（SOD），谷胱甘肽过氧化物酶（GPx）和过氧化氢酶（CAT）。该文献的系统综述的目的是介绍有关牙周炎患者牙龈液，唾液和血清中这些抗氧化酶活性的最新研究。到目前为止，在分类为牙周炎（慢性或侵袭性）的牙周炎过程中，关于这些酶在牙龈组织，牙龈液，唾液和血清中的活性的发现非常不同。它们在牙龈组织中的活性通常升高，而在唾液中的活性降低。这些差异可能是由于生物化学评估其活性的不同方法所致，并且可能尚未反映出牙周炎的发展阶段和/或风险。

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