Synthesis and antibacterial screening of some 2-(p-substituted benzylidene)-3-(5-propyl-1, 3, 4-thiadiazol-2-yl) thiazolidin-4- ones

Sunil Kumar; S. K. Sharma; eep Jain

首页> 外文期刊>Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry >Synthesis and antibacterial screening of some 2-(p-substituted benzylidene)-3-(5-propyl-1, 3, 4-thiadiazol-2-yl) thiazolidin-4- ones

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Synthesis and antibacterial screening of some 2-(p-substituted benzylidene)-3-(5-propyl-1, 3, 4-thiadiazol-2-yl) thiazolidin-4- ones

机译：某些2-（对位取代亚苄基）-3-（5-丙基-1，3，4-噻二唑-2-基）噻唑烷-4-的合成及抗菌筛选

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A series of 2-(p-substituted benzylidene)-3-(5-propyl-1, 3, 4-thiadiazol-2-yl) thiazolidin-4-ones were synthesized by the reaction of Schiff’s bases of N-(p-substituted benzylidene)-5 propyl -1, 3, 4-thiadiazole-2-amines with thioglycolic acid in 1, 4-dioxane as solvent and studied for their in vitro antibacterial activity. Reaction of thiosemicarbazide with butanoic acid in presence of concentrated sulphuric acid led to the formation of 5-propyl-1, 3, 4-thiadiazole-2-amines which on further reaction with different p-substituted benzaldehydes yielded the compounds Schiff’s bases of N-(p-substituted benzylidene)-5- propyl -1,3, 4-thiadiazole-2-amines which is further reaction with thioglycollic acid in presence of small amount of zinc chloride in 1,4 dioxane as solvent gave title compounds. These compounds were characterized by spectral analysis. All the synthesized compounds were evaluated for their in vitro for their antibacterial activity against two Gram positive bacterial strains (Bacillus subtilis and Staphylococcus aureus) and two Gram negative bacterial strains (Escherichia coli and Pseudomonas aeruginosa) and their minimum inhibitory concentration (MIC) were determined.

机译：通过N-（p-的Schiff碱的反应，合成了一系列的2-（对取代的亚苄基）-3-（5-丙基-1,3,4-噻二唑-2-基）噻唑烷-4-酮。以1,4-二恶烷为溶剂的巯基乙酸取代取代的亚苄基）-5丙基-1，3，4-噻二唑-2-胺，并对其体外抗菌活性进行了研究。在浓硫酸存在下，硫代氨基脲与丁酸的反应导致形成5-丙基-1,3,4-噻二唑-2-胺，进一步与不同的对位取代的苯甲醛反应，生成了N-的席夫碱。（p-取代的亚苄基）-5-丙基-1,3,4-噻二唑-2-胺在少量氯化锌的存在下，在1,4-二恶烷中作为溶剂与硫代乙醇酸进一步反应，得到标题化合物。这些化合物通过光谱分析表征。评价所有合成的化合物在体外对两种革兰氏阳性细菌菌株（枯草芽孢杆菌和金黄色葡萄球菌）和两种革兰氏阴性细菌菌株（大肠杆菌和铜绿假单胞菌）的抗菌活性，并确定其最低抑菌浓度（MIC）。。

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《Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry》 |2016年第12期|共6页
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Sunil Kumar; S. K. Sharma; eep Jain;
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Synthesis and antibacterial screening of some 2-(p-substituted benzylidene)-3-(5-propyl-1, 3, 4-thiadiazol-2-yl) thiazolidin-4- ones

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