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首页> 外文期刊>Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry >Regulatory Effects of Morus alba Aqueous Leaf Extract in Streptozotocin-Induced Diabetic Nephropathy
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Regulatory Effects of Morus alba Aqueous Leaf Extract in Streptozotocin-Induced Diabetic Nephropathy

机译：桑叶水提取物对链脲佐菌素诱发的糖尿病肾病的调节作用

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This study aimed to investigate the effects of aqueous leaf extract of Morus alba on biochemical and histological changes in streptozotocin (STZ)-induced diabetic nephropathy. Male Wister albino rats were divided into five groups of six each: Group 1: Control group; received citrate buffer for 10 days. Group 2: Untreated diabetic rats injected intraperitoneally with 50 mg/kg of STZ; received distilled water for 10 days. Group 3-5: Diabetic rats; received Glimepiride and M. alba in 2 dose levels (250 and 500 mg/kg) for 10 days, orally. STZ-diabetic rats exhibited hyperglycemia accompanied with increased α-amylase levels, total cholesterol (TC) and kidney function, on the other hand, reduced high density lipoprotein cholesterol (HDL-C) and total antioxidant capacity (TAC) levels. Morus alba in its 2 dose levels (250 and 500 mg/kg) showed a significant lowering effect in serum glucose, α-amylase, TC levels and kidney function as well as increasing serum HDL-C and TAC levels comparable to STZ diabetic group. Microscopic examination of the pancreatic sections and kidney of diabetic rats treated with M. alba at higher dose revealed approximately normal structure, compared with STZ diabetic group. These results indicate that treatment with aqueous extract of M. alba may be effective in STZ- induced diabetic nephropathy as it showed higher hypoglycemic and hypolipidemic properties with more down-regulation of α-amylase and restore kidney function than, reference drug, Glimepiride potancy.
机译：这项研究旨在调查桑叶水提取物对链脲佐菌素（STZ）诱导的糖尿病性肾病的生化和组织学变化的影响。将雄性Wister白化病大鼠分为五组，每组六只：第1组：对照组;第2组：对照组。接受柠檬酸盐缓冲液10天。第2组：未经治疗的糖尿病大鼠腹膜内注射50mg / kg的STZ。接受蒸馏水10天。 3-5组：糖尿病大鼠;口服给予格列美脲和白念珠菌2种剂量水平（250和500 mg / kg），持续10天。 STZ糖尿病大鼠表现出高血糖症，并伴有α-淀粉酶水平，总胆固醇（TC）和肾功能增加，另一方面，高密度脂蛋白胆固醇（HDL-C）和总抗氧化能力（TAC）水平降低。桑树的2种剂量水平（250和500 mg / kg）显示出与STZ糖尿病组相当的降低血糖，α-淀粉酶，TC水平和肾功能以及增加血清HDL-C和TAC水平的作用。与STZ糖尿病组相比，用高剂量的白念珠菌治疗的糖尿病大鼠的胰腺切片和肾脏的显微镜检查显示出大致正常的结构。这些结果表明，与参考药物格列美脲效价相比，用白僵菌的水提取物治疗可能对STZ诱导的糖尿病性肾病有效，因为它显示出更高的降血糖和降血脂特性，α-淀粉酶的下调更多，并且可以恢复肾脏功能。

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