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首页> 外文期刊>Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry >Validated visible spectrophotometric methods for determination of Zileuton in pharmaceutical formulation
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Validated visible spectrophotometric methods for determination of Zileuton in pharmaceutical formulation

机译：经验证的可见分光光度法测定药物制剂中的齐留通

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摘要

The present study describes two simple and selective spectrophotometric methods for the determination of zileuton in bulk and tablet formulation. Two methods were based on the oxidation of zileuton with ferric chloride followed by complex formation with 1, 10-Phenanthroline (Method A) and 2, 2’-Bipyridine (Method B). The resulting red colored chromogens are measured at 510 nm and 523 nm in the concentration ranges of 5-30 μg/ml and 5-30 μg/ml for method A and method B respectively. The proposed methods were applied successfully to determine zileuton in tablet form without interference from excipients present in pharmaceutical formulation. The results of analysis have been validated statistically and by recovery methods.
机译：本研究描述了两种简单且选择性的分光光度法测定散装和片剂中齐留通的含量。两种方法是基于用氯化铁氧化齐留通，然后与1，10-菲咯啉（方法A）和2，2'-联吡啶（方法B）形成复合物。对于方法A和方法B，在510 nm和523 nm处分别在5-30μg/ ml和5-30μg/ ml的浓度范围内测量所得的红色色原。所提出的方法已成功应用于片剂形式的齐留通测定，而不受药物制剂中赋形剂的干扰。分析结果已通过统计学方法和回收方法进行了验证。

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