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首页> 外文期刊>Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry >Simultaneous HPTLC Determination of Paracetamol and Dexketoprofen trometamol in pharmaceutical dosage form
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Simultaneous HPTLC Determination of Paracetamol and Dexketoprofen trometamol in pharmaceutical dosage form

机译：高效液相色谱法同时测定药物剂型中扑热息痛和右旋酮洛芬

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摘要

A fast, simple, precise, accurate and robust HPTLC method was developed for simultaneous determination of paracetamol and dexketoprofen trometamol in tablet dosage form. Silica gel G 60F254 plates were used as stationary phase and toluene: ethyl acetate: acetic acid (6: 4: 0.2 v/v/v) as mobile phase. Wavelength selected for analysis was 256 nm. The two drugs were satisfactorily resolved with Rf 0.20 ± 0.02 and 0.55 ± 0.02 for paracetamol and dexketoprofen trometamol respectively. Linearity was found to be in the range of 25-150 ng/spot for paracetamol, 100-600 ng/spot for dexketoprofen trometamol. Intra-day and inter-day precision were found to be (%RSD) 0.94–1.58 % and 1.14–1.83 % for paracetamol and (%RSD) 0.67–1.03 % and 0.49–1.18 for dexketoprofen trometamol. Accuracy of paracetamol and dexketoprofen trometamol was found to be 99.91 % and 99.56 %, respectively. The proposed method can be used for routine simultaneous analysis of paracetamol and dexketoprofen trometamol.
机译：开发了一种快速，简单，精确，准确和可靠的HPTLC方法，用于同时测定片剂剂型中的扑热息痛和右旋苯丙酸苯丁胺醇。硅胶G 60F254板用作固定相，甲苯：乙酸乙酯：乙酸（6：4：0.2 v / v / v）用作流动相。选择进行分析的波长为256 nm。两种药物分别以扑热息痛和右酮洛芬曲美他莫的Rf 0.20±0.02和0.55±0.02令人满意地分离。发现对乙酰氨基酚的线性在25-150 ng /点的范围内，对于右酮洛芬曲美他莫的线性在100-600 ng /点的范围内。发现对乙酰氨基酚的日内和日间精密度分别为（％RSD）0.94–1.58％和1.14–1.83％，而右酮洛芬特洛美他莫的（％RSD）0.67–1.03％和0.49–1.18。扑热息痛和右酮洛芬曲美他莫的准确度分别为99.91％和99.56％。所提出的方法可用于扑热息痛和右酮洛芬曲美他酚的常规同时分析。

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