Synthesis and characterization of novel benzothiophene substituted oxadiazole derivatives and their antimicrobial activity.

H. K. Nagesh; Basavaraj Padmashali; C. S; eep; T. E. Musturappa; M. R Lokesh

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Synthesis and characterization of novel benzothiophene substituted oxadiazole derivatives and their antimicrobial activity.

机译：新型苯并噻吩取代的恶二唑衍生物的合成，表征及其抗菌活性。

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The compound 2 was refluxed with various acetophenones and benzaldehydes to produce Schiff’s bases 4a-e and 6a-e. The reaction of these Schiff’s bases with acetic anhydride and phosphorous oxychloride to give benzothiophene linked 2, 5-disubstituted-1,3,4-oxadiazoles 5a-e and 7a-e. The compound 2 was directly cyclized by refluxing with phosphorus oxychloride to give benzothiophene substituted oxadiazoles 3a-e. All the newly synthesized compounds were screened for their antimicrobial activity and were characterized by elemental analyses, IR, 1H NMR and mass spectral data.

机译：化合物2与各种苯乙酮和苯甲醛回流，生成席夫碱4a-e和6a-e。这些席夫氏碱与乙酸酐和氯氧化磷反应，生成苯并噻吩连接的2、5-二取代-1,3,4-恶二唑5a-e和7a-e。通过与三氯氧化磷回流直接将化合物2环化，得到苯并噻吩取代的恶二唑3a-e。筛选所有新合成的化合物的抗菌活性，并通过元素分析，IR，1H NMR和质谱数据进行表征。

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《Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry》 |2015年第12期|共8页
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H. K. Nagesh; Basavaraj Padmashali; C. S; eep; T. E. Musturappa; M. R Lokesh;
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Synthesis and characterization of novel benzothiophene substituted oxadiazole derivatives and their antimicrobial activity.

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