...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry >Synthesis, Characterization and Antiulcer Activity of Halogen Containing Chalcones
【24h】

Synthesis, Characterization and Antiulcer Activity of Halogen Containing Chalcones

机译：含卤素查耳酮的合成，表征和抗溃疡活性

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In the present study, a series of ten chalcone derivatives were synthesized by Claisen-Schmidt condensation and evaluated for their antiulcer activity. Chalcones are a group of naturally occurring compounds and precursor of flavonoids, isoflavonoids and important constituents of natural products such as fruits, vegetables, spices, tea and soya based food stuff. The structures of the compounds were characterized by Infra-Red (IR), Proton Nuclear Magnetic Resonance (1H-NMR) and mass spectral analysis. All the chalcones were evaluated for their antiulcer activity by using albino rats and the activity was measured by using methanol induced gastric ulcer model. The results of the best synthesized chalcones suggested that the presence of electron releasing groups and halogen moieties on aromatic ring showed best antiulcer activity and it was measured in terms of % antiulcer activity.
机译：在本研究中，通过Claisen-Schmidt缩合反应合成了一系列十个查尔酮衍生物，并评估了它们的抗溃疡活性。查尔酮是一组天然存在的化合物，是类黄酮，异类黄酮和天然产物（例如水果，蔬菜，香料，茶和大豆类食品）的重要成分的前体。通过红外（IR），质子核磁共振（1H-NMR）和质谱分析对化合物的结构进行表征。用白化病大鼠评价所有查耳酮的抗溃疡活性，并用甲醇诱导的胃溃疡模型测定其活性。最佳合成查耳酮的结果表明，芳香环上电子释放基团和卤素部分的存在显示出最佳的抗溃疡活性，并以抗溃疡活性％来衡量。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号