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首页> 外文期刊>Developmental Immunology: Journal of Immunology Research >Transfusion Related Acute Lung Injury (TRALI) Caused by Red Blood Cell Transfusion Involving Residual Plasma Anti-HLA Antibodies: A report on two Cases and General Considerations
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Transfusion Related Acute Lung Injury (TRALI) Caused by Red Blood Cell Transfusion Involving Residual Plasma Anti-HLA Antibodies: A report on two Cases and General Considerations

机译：涉及残余血浆抗HLA抗体的红细胞输血引起的与输血相关的急性肺损伤（TRALI）：两例报告和一般考虑

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摘要

TRALI is considered a serious hazard among immune complications of blood transfusion and its occurrence is admitted to be globally underestimated. Each type of blood product is likely to cause TRALI. We report here on two consecutive observations of TRALI caused by red blood cell concentrates, in which anti-HLA class I and class II antibodies resulting from post-gravitational allo-immunization were evidenced in donors. HLA class I and II antigenic community between recipients and donors' husbands were found and strong reacting IgG antibodies directed at several of those common antigens were detected in the donors' serum. Both donors had more than 3 pregnancies, raising the issue of blood donor selection or of plasma reduction for cellular products.
机译：TRALI被认为是输血免疫并发症中的一种严重危害，其发生被认为在全球范围内被低估了。每种类型的血液制品都可能导致TRALI。我们在这里报告了由红细胞浓缩物引起的TRALI的两个连续观察结果，其中在供体中证实了重力后同种免疫产生的抗HLA I类和II类抗体。发现了受体和供体的丈夫之间的HLA I和II类抗原共同体，并且在供体的血清中检测到了针对其中一些常见抗原的强烈反应的IgG抗体。两位捐献者都怀孕了3次以上，这增加了献血者选择或减少细胞产品血浆的问题。

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