• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Diagnostic and therapeutic endoscopy >Detection of Photofrin Fluorescence From Malignant and Premalignant Lesions in the Bronchus using a Full-color Endoscopic Fluorescence Imaging System
【24h】

Detection of Photofrin Fluorescence From Malignant and Premalignant Lesions in the Bronchus using a Full-color Endoscopic Fluorescence Imaging System

机译：使用全色内窥镜荧光成像系统检测支气管恶性和恶变前病变中的光敏蛋白荧光

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Study objectives: To detect invisible lung cancer and to determine field of laser radiationduring PDT we developed a full-color fluorescence fiberscopic system. We tested the efficacyof this system in patients with various bronchial malignancies.System design: A fiber-optic endoscope was attached to a camera box containing a colorICCD camera which can detect from 400 to 700nm fluorescence in full-color. Light ofaverage wavelength 405 nm was selected and radiated through the light channel of thefiberscope from a 300W Xenon lamp.Patients and methods: We examined nine consecutive patients with bronchial malignancyadmitted in our hospital to receive PDT. Sixteen lesions in these nine patients were observedwith white light and excitation light and the results were compared. Histological examinationswere done by taking biopsy specimens and samples for pathological and cytologicalexamination. After the diagnosis was confirmed, 2.0 mg/kg Photofrin was injected. Forty eighthours after the administration of Photofrin, observation of the bronchial wall was made usinga full-color endoscopic fluorescence imaging system just before PDT.Results: Bright red fluorescence from Photofrin was Observed in 14/14 bronchialmalignancies: 3 squamous cell carcinoma, 9 squamous cell carcinomain situ, 1 metastaticbreast cancer and 1 metastatic islet cell tumor. Bright red fluorescence was also detected in 2/2squamous dysplasia. Green autofluorescence was observed in the normal part of the bronchus.Conclusions: Results of the present study suggest that the full-color endoscopicfluorescence imaging system can be used to detect malignant and premalignant lesions as redfluorescence against green autofluorescence with Photofrin administration, and this system has the potential to detect absence of autofluorescence in cancerous lesions.
机译：研究目标：为了检测隐形肺癌并确定PDT期间的激光辐射范围，我们开发了一种全色荧光纤维镜系统。我们测试了该系统在各种支气管恶性肿瘤患者中的功效。系统设计：将光纤内窥镜连接到装有colorICCD相机的相机盒上，该相机可以检测400至700nm的全色荧光。选择平均波长为405 nm的光，并通过300W氙气灯通过纤维镜的光通道辐射。患者和方法：我们检查了我院连续9例接受PDT的支气管恶性肿瘤患者。用白光和激发光观察这9例患者中的16例病变，并比较结果。组织学检查是通过抽取活检标本和样本进行病理学和细胞学检查来进行的。确认诊断后，注射2​​.0 mg / kg Photofrin。施用Photofrin后48小时，在PDT之前使用全色内镜荧光成像系统观察支气管壁。结果：在14/14支气管恶性肿瘤中观察到Photofrin发出的鲜红色荧光：3个鳞状细胞癌，9个鳞状细胞癌。原位癌，1例转移性乳腺癌和1例转移性胰岛细胞瘤。在2/2鳞状不典型增生中也检测到亮红色荧光。结论：本研究结果表明，全色内窥镜荧光成像系统可用于检测恶性和恶变前病变，如通过使用Photofrin施用的红色荧光对抗绿色自发荧光，该系统具有在癌症病变中检测自身荧光缺失的潜力。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号