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首页> 外文期刊>Applied optics >Clinical imaging fluorescence apparatus for the endoscopic photodetection of early cancers by use of Photofrin II
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Clinical imaging fluorescence apparatus for the endoscopic photodetection of early cancers by use of Photofrin II

机译：使用Photofrin II在内窥镜下对早期癌症进行光检测的临床成像荧光仪

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A fluorescence imaging device applied to the detection of early cancer is described. The apparatus is based on the imaging of laser-induced fluorescence of a dye that localizes in a tumor with a higher concentration than in the surrounding normal tissue after iv injection. Tests carried out in the upper aerodigestive tract, the tracheobronchial tree, and the esophagus with Photofrin II (1 mg/kg of body weight) as the fluorescent agent are reported as examples. The fluorescence is induced by violet (410-nm) light from a continuous-wave (cw) krypton-ion laser. The fluorescence contrast between tumor and surrounding tissue is enhanced bg real-time image processing, This is done by the simultaneous recording of the fluorescence image in two spectral domains (470-600 and 600-720 nm), after which these two images are digitized and manipulated with a mathematical operator (look-up table) at video frequency, Among the 7 photodetections performed in the tracheobronchial tree, 6 were. successful, whereas it was the case for only 5 of the 15 lesions investigated in squamous mucosa (upper aerodigestive tract and esophagus). The sources of false positives and false negatives are evaluated in terms of the fluorescent dye, tissue optical properties, and illumination optics. (C) 1991 Optical Society of America.
机译：描述了一种应用于早期癌症检测的荧光成像装置。该设备基于对染料进行激光诱导的荧光成像，该染料在静脉注射后以比周围正常组织更高的浓度定位在肿瘤中。据报道，以Photofrin II（1 mg / kg体重）作为荧光剂，在上消化道，气管支气管树和食道中进行了测试。荧光是由连续波（cw）ion离子激光器发出的紫光（410-nm）引起的。实时图像处理增强了肿瘤与周围组织之间的荧光对比，这是通过同时记录两个光谱域（470-600和600-720 nm）中的荧光图像来完成的，然后将这两个图像数字化并由数学运算符（查找表）在视频频率下进行操作。在气管支气管树中进行的7次光电检测中，有6次是光电检测。成功的是，鳞状粘膜（上消化道和食道）的15个病变中只有5个是这种情况。根据荧光染料，组织光学特性和照明光学评估假阳性和假阴性的来源。 （C）1991年美国眼镜学会。

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