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首页> 外文期刊>The Egyptian Journal of Neurology, Psychiatry and Neurosurgery >Role of Serum S100B Protein in Prediction of Outcome of Malignant Middle Cerebral Artery Infarction: Clinical and Laboratory Study
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Role of Serum S100B Protein in Prediction of Outcome of Malignant Middle Cerebral Artery Infarction: Clinical and Laboratory Study

机译：血清S100B蛋白在预测恶性中脑动脉梗死结果中的作用：临床和实验室研究

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Background: Early prediction of outcome in patients with malignant middle cerebral artery infarction may help the proper choice for the therapeutic decision in this stroke subtype. Objective: We attempted to investigate the possible role of serum S100 B protein, beside other clinical and radiological determinants, in prediction of outcome of malignant cerebral infarction. Methods: This study was conducted on 42 stroke patients with clinical and radiological evidence of malignant cerebral infarction (group I), and 20 patients with non malignant cerebral infarction as a morbid control (group II), in addition to 20 individuals as a healthy control (group III). Assessment of the disability was done by modified Rankin Scale, which was performed after one week, then after one month and after three months of admission. Computerized tomography of the brain was done for all patients on admission, and was repeated after one week for group I patients. Serum S100 B protein was measured initially for the three groups and after one week for group I patients. Results: the serum S100B protein value on admission was significantly higher in group I patients when compared to both group II and group III patients. Follow up values were increased but without significant difference from the initial values in group I patients. Moreover, the S100B value was significantly related to the mortality outcome. Conclusion: Serum S100B protein on admission (beside other clinical and radiological predictors) can predict the outcome of malignant middle cerebral artery infarction. [Egypt J Neurol Psychiat Neurosurg.  2012; 49(2): 157-164]
机译：背景：恶性大脑中动脉梗死患者的早期结果预测可能有助于正确选择该卒中亚型的治疗决策。目的：我们试图探讨血清S100 B蛋白以及其他临床和放射学决定因素在预测恶性脑梗死预后中的可能作用。方法：本研究针对42例具有临床和影像学证据的恶性脑梗死患者（I组）和20例非恶性脑梗塞患者作为病态对照（II组），以及20例健康对照者（第三组）。通过改良的兰金量表对残疾进行评估，该量表在入院后一周，之后一个月和三个月后进行。入院时对所有患者进行了脑部计算机断层扫描，第一组患者在一周后重复进行此操作。最初在三组中测量血清S100 B蛋白，在第一周后测量一周。结果：与第二组和第三组患者相比，第一组患者入院时血清S100B蛋白值显着更高。随访值增加，但与第一组患者的初始值无明显差异。此外，S100B值与死亡率结果显着相关。结论：入院时血清S100B蛋白（与其他临床和影像学预测指标并列）可预测恶性脑中动脉梗塞的预后。 [埃及J Neurol精神病神经外科。 2012; 49（2）：157-164]

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