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首页> 外文期刊>The Egyptian Journal of Neurology, Psychiatry and Neurosurgery >Cervical Radicular Pain Induced Neuroplasticity in Somatosensory Pathway
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Cervical Radicular Pain Induced Neuroplasticity in Somatosensory Pathway

机译：颈椎痛在体感通路中诱导神经可塑性

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Background: Peripheral deafferentation is known to induce neuroplastic changes in the neuronal system, but there is paucity in studies addressing pain influence on neuroplasticity. Objective: To assess the relationship between chronic pain and plasticity in somatosensory pathway. Methods: A cross sectional study including 20 Egyptian patients with unilateral cervical radicular pain. Patients were neurologically assessed and pain severity was graded. Magnetic resonance imaging of the cervical spine, and electromyography, for evidence of deafferentation, were performed. Somatosensory evoked potential studies after digital nerve stimulation of thumb, little finger on painful and non painful sides were done. Somatosensory evoked potential parameters were compared within individual patients and with those of 10 age and sex matched control subjects. Results: Pain severity was graded as II in 13 patients and III in 7. The 6th cervical root was the most involved root clinically and radiologically. There was no evidence of deafferentation in 75% of patients. Amplitudes of EP, N13, N20 and P22 after stimulation of the painful thumb were greater than those of the non-painful thumb, little finger on painful and non painful sides within patients group and those of controls. The amplitude difference of EP showed the least change relative to other waves among patients. The amplitudes correlated with pain severity and duration. Conclusion: Pain can induce neuroplastic changes within the somatosensory pathway, irrespective of presence of deafferentation, involving both peripheral and central levels but more evident centrally. Such changes are selective to the involved territory. [Egypt J Neurol Psychiat Neurosurg.  2012; 49(1): 59-66]
机译：背景：周围的脱除咖啡因会引起神经系统神经胶质的改变，但是有关疼痛对神经胶质的影响的研究却很少。目的：探讨体感途径中慢性疼痛与可塑性之间的关系。方法：一项横断面研究，包括20名埃及单侧颈神经根痛患者。对患者进行了神经学评估，并对疼痛严重程度进行了分级。进行了颈椎的磁共振成像和肌电图检查，以显示脱除咖啡因。在拇指，小指疼痛和非疼痛侧的手指神经刺激后，进行了体感诱发电位研究。在个体患者中以及与10个年龄和性别相匹配的对照对象中比较了体感诱发电位参数。结果：13例患者的疼痛严重程度被定为II级，7例被定为III级。第六个颈椎根是临床和放射学上涉及最多的根。没有证据表明有75％的患者会脱除咖啡因。疼痛拇指的刺激后，EP，N13，N20和P22的幅度大于非疼痛拇指，小手指在患者组和对照组中疼痛和非疼痛侧的幅度。在患者中，相对于其他波，EP的幅度差异显示出最小的变化。振幅与疼痛的严重程度和持续时间相关。结论：疼痛可引起体感通路内的神经增生变化，无论是否存在脱除咖啡因，都涉及外周和中枢水平，但在中枢更为明显。这种变化对所涉领土是有选择性的。 [埃及J Neurol精神病神经外科。 2012; 49（1）：59-66]

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