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首页> 外文期刊>The Egyptian Journal of Hospital Medicine >Preoperative Pregabalin Prolongs Duration of Spinal Anesthesia and Reduces Early Postoperative Pain
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Preoperative Pregabalin Prolongs Duration of Spinal Anesthesia and Reduces Early Postoperative Pain

机译：术前普瑞巴林延长脊髓麻醉的持续时间并减少术后早期疼痛

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Background: Various adjuvants have been used to prolong spinal anesthesia, with the additional advantages of delaying the onset of postoperative pain and reducing postoperative analgesic requirements. Pregabalin is an R- aminobutyric acid analog that binds to the 2- subunit of presynaptic voltage-gated calcium channels. Objective: The aim of this work is to evaluate the efficacy of a single dose of pregabalin in terms of spinal blockade duration and its potential opioid-sparing effect during the first 24 hours postoperatively Patients and Methods: There were limitations to the present study. First, since only 1 dosage of pregabalin was evaluated, we could not determine the most effective dosage. Second, clinically meaningful improvements in recovery were not assessed. Adequate postoperative pain control provides early postsurgical mobilization, shortened hospitalization, and increased patient satisfaction. Third, preoperative pain and anxiety scores were not recorded. Pregabalin might affect the preoperative pain, mood, and anxiety scores, and these factors can be related to the postoperative pain score. Results: The mechanisms by which pregabalin premedication prolongs motor and sensory blocks using local anesthetics in spinal anesthesia are not fully understood. There may be several reasons for the prolongation of spinal anesthesia. Gabapentinoids are an r - aminobutyric acid analog that binds to 2- subunit of presynaptic voltage-gated calcium channels, and this inhibition decreases postsynaptic excitability by reducing potassium- evoked excitatory transmitter release. These medications provide antiepileptic, anxiolytic, and analgesic features by modulating both GABAergic neurotransmission and calcium influx. Gabapentinoid compounds produce a significant and clinically important improvement in preoperative anxiety scores. Since patients may be anxious in the perioperative period, the anxiolytic effects and euphorigenic effects of pregabalin may be beneficial.
机译：背景：已经使用了各种佐剂来延长脊髓麻醉的时间，其另外的优点是延迟了术后疼痛的发作并减少了术后镇痛的需要。普瑞巴林（Pregabalin）是一种R-氨基丁酸类似物，可与突触前电压门控钙通道的2-亚基结合。目的：这项工作的目的是评估术前24小时内单剂量普瑞巴林的疗效，以评估其脊髓阻滞持续时间及其潜在的阿片类药物保留作用。患者和方法：本研究存在局限性。首先，由于仅评估了1种普瑞巴林剂量，因此我们无法确定最有效的剂量。其次，未评估临床上有意义的恢复改善。适当的术后疼痛控制可尽早进行术后动员，缩短住院时间并提高患者满意度。第三，未记录术前疼痛和焦虑评分。普瑞巴林可能会影响术前疼痛，情绪和焦虑评分，这些因素可能与术后疼痛评分有关。结果：在脊髓麻醉中使用局部麻醉剂进行普瑞巴林的前期用药延长运动和感觉阻滞的机理尚未完全明了。延长脊髓麻醉可能有多种原因。 Gabapentinoids是一种r-氨基丁酸类似物，与突触前电压门控钙通道的2个亚基结合，这种抑制作用通过减少钾诱发的兴奋性递质释放而降低了突触后兴奋性。这些药物通过调节GABA能神经传递和钙内流来提供抗癫痫，抗焦虑和镇痛作用。加巴喷丁化合物在术前焦虑评分上产生了显着且临床上重要的改善。由于患者可能在围手术期感到焦虑，因此普瑞巴林的抗焦虑作用和欣快作用可能是有益的。

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