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首页> 外文期刊>The Egyptian Journal of Neurology, Psychiatry and Neurosurgery >Neuropsychiatric Systemic Lupus Erythematosus: Magnetic Resonance Spectroscopic Study
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Neuropsychiatric Systemic Lupus Erythematosus: Magnetic Resonance Spectroscopic Study

机译：神经精神系统性红斑狼疮：磁共振波谱研究。

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Background: Although clinical assessment is still the cornerstone in the diagnosis of neuropsychiatric SLE (NPSLE), the diagnosis is often difficult. Proton magnetic spectroscopy (1H-MRS) has the ability to detect neurochemical brain abnormalities even in normal MRI areas in these patients. Objective: To evaluate the spectral brain changes using 1H-MR spectroscopy in NPSLE patients, and correlate their NP clinical data with  MRI and 1H-MRS abnormalities. Methods: 23 NPSLE patients and 8 healthy controls were included in this study. Neuropsychological tests were applied to all patients and controls for detection of impairment in any cognitive domains. Patients were classified into two groups; the first included NPSLE patients with normal MRI, while the other group with abnormal MRI. Single voxel proton MRS using point resolved spectroscopy sequence were evaluated in the parieto-occipital white matter in all patients and volunteers and in areas of MRI abnormal lesions. The relative ratios of NAA to Cr and Cho to Cr were measured. Results: Patients age ranged from 18-36, with mean±SD was 26.45±5.65 years, the most common NP features were headache and cognitive impairment with 39.1% for each of them, 9 patients (39.1%) had abnormal MRI imaging, while, spectral changes present in 20 patients (86.9%). MRS showed a significantly decreased NAA/Cr ratio and increased Cho/Cr ratio. In patients with abnormal MRI, the NAA/Cr ratio was significantly lower than those with normal MRI and control groups while the Cho/Cr ratio was significantly higher. Conclusion: In patients with NPSLE, 1H-MR spectroscopic findings seem to reflect the cerebral metabolic disturbances as functional abnormalities, related to the NP symptoms and it is a complementary tool to MRI as anatomical abnormalities in diagnosing the CNS involvement. [Egypt J Neurol Psychiat Neurosurg.  2011; 48(4): 359-366]
机译：背景：尽管临床评估仍然是诊断神经精神性SLE（NPSLE）的基石，但诊断通常很困难。质子磁共振波谱（1H-MRS）甚至能够在这些患者的MRI正常区域中检测神经化学性脑部异常。目的：使用1H-MR光谱法评估NPSLE患者的脑光谱变化，并将其NP临床数据与MRI和1H-MRS异常相关联。方法：本研究包括23例NPSLE患者和8例健康对照。将神经心理学测试应用于所有患者和对照，以检测任何认知领域的损伤。将患者分为两组。第一组包括MRI正常的NPSLE患者，而另一组MRI异常。在所有患者和志愿者以及MRI异常病变区域的顶枕白质中评估了使用点分辨光谱序列的单个体素质子MRS。测量了NAA与Cr的相对比例和Cho与Cr的相对比例。结果：患者年龄在18-36岁之间，平均±SD为26.45±5.65岁，最常见的NP特征为头痛和认知障碍，分别为39.1％，其中9例（39.1％）MRI成像异常，而，频谱变化存在于20位患者中（86.9％）。 MRS显示NAA / Cr比显着降低，而Cho / Cr比增加。 MRI异常的患者中，NAA / Cr比值显着低于正常MRI和对照组，而Cho / Cr值则显着较高。结论：在NPSLE患者中，1H-MR光谱学检查结果似乎反映出脑代谢紊乱是功能异常，与NP症状有关，它是MRI作为解剖异常诊断CNS的辅助工具。 [埃及J Neurol精神病神经外科。 2011; 48（4）：359-366]

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