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首页> 外文期刊>The Egyptian Rheumatologist >Serum leptin and osteoporosis in postmenopausal women with primary knee osteoarthritis
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Serum leptin and osteoporosis in postmenopausal women with primary knee osteoarthritis

机译：绝经后原发性膝骨性关节炎妇女的血清瘦素和骨质疏松症

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Aim of the work The purpose of this study was to evaluate the relationship of serum leptin level and osteoporosis in postmenopausal women with knee osteoarthritis (KOA). Patients and methods The study included 40 postmenopausal women with primary KOA and 37 age-matched postmenopausal healthy controls. Plain X-ray knees were performed and assessed using the Kellgren–Lawrence (KL) grading scale. Bone mineral density (BMD) was assessed using dual-energy X-ray absorptiometry (DXA) in lumbar spine, hip and forearm regions. As a bone turn-over marker serum osteocalcin was measured. Serum leptin level was assessed in patients and control. Results The mean age of the KOA patients was 58.05 ± 5.7 years. Osteoporosis was detected among 15% of the KOA patients and 35.1% of the control. The BMD was significantly increased at the spine and wrist in the patients than in the control ( p = 0.011 and p = 0.015 respectively). The serum osteocalcin was comparable between patients (19.74 ± 8.05 ng/ml) and control (21.2 ± 8.36 ng/ml) ( p = 0.5). Serum leptin was significantly higher in the patient (58.7 ± 27.17 ng/ml) compared to the control (48.75 ± 13.19 ng/ml) ( p = 0.048), and significantly correlated with the degree of KOA ( p = 0.017). No significant correlation was found between serum osteocalcin level or the BMD and the degree of KOA. There was a significant negative correlation between serum osteocalcin level and forearm BMD in KOA patients ( r = ?0.33, p = 0.038). Conclusions Although postmenopausal women with KOA had significantly higher BMD, both diseases can coexist. It seemed that osteoarthritis does not prevent the occurrence of osteoporosis. Our study suggested a promising role of leptin as a biomarker of KOA.
机译：工作的目的本研究的目的是评估绝经后女性膝骨关节炎（KOA）的血清瘦素水平与骨质疏松的关系。患者和方法该研究包括40名绝经后原发性KOA妇女和37名年龄匹配的绝经后健康对照。使用Kellgren-Lawrence（KL）分级量表对X射线平直膝盖进行评估。使用双能X线骨密度仪（DXA）评估腰椎，臀部和前臂区域的骨矿物质密度（BMD）。测定骨钙素作为骨转换标志物。在患者和对照中评估血清瘦素水平。结果KOA患者的平均年龄为58.05±5.7岁。在15％的KOA患者和35.1％的对照组中检测到骨质疏松症。与对照相比，患者的脊柱和腕部骨密度明显增加（分别为p = 0.011和p = 0.015）。患者（19.74±8.05 ng / ml）和对照组（21.2±8.36 ng / ml）之间的血清骨钙素水平相当（p = 0.5）。与对照组（48.75±13.19 ng / ml）相比，患者的血清瘦素（58.7±27.17 ng / ml）显着更高（p = 0.048），并且与KOA程度显着相关（p = 0.017）。血清骨钙素水平或BMD与KOA程度之间无显着相关性。 KOA患者的血清骨钙素水平与前臂BMD呈显着负相关（r = 0.33，p = 0.038）。结论尽管绝经后KOA妇女的BMD明显升高，但两种疾病均可共存。看来骨关节炎并不能预防骨质疏松症的发生。我们的研究表明，瘦素作为KOA的生物标志物具有广阔的前景。

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