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首页> 外文期刊>Drug Design, Development and Therapy >Effect of tocotrienol from Bixa orellana (annatto) on bone microstructure, calcium content, and biomechanical strength in a model of male osteoporosis induced by buserelin
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Effect of tocotrienol from Bixa orellana (annatto) on bone microstructure, calcium content, and biomechanical strength in a model of male osteoporosis induced by buserelin

机译：桦木（Bixa orellana）的生育三烯酚（annatto）对Buserelin诱发的男性骨质疏松模型中骨微结构，钙含量和生物力学强度的影响

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Background: Patients receiving androgen deprivation therapy experience secondary hypogonadism, associated bone loss, and increased fracture risk. It has been shown that tocotrienol from Bixa orellana (annatto) prevents skeletal microstructural changes in rats experiencing primary hypogonadism. However, its potential in preventing bone loss due to androgen deprivation therapy has not been tested. This study aimed to evaluate the skeletal protective effects of annatto tocotrienol using a buserelin-induced osteoporotic rat model. Methods: Forty-six male Sprague Dawley rats aged 3?months were randomized into six groups. The baseline control (n=6) was sacrificed at the onset of the study. The normal control (n=8) received corn oil (the vehicle of tocotrienol) orally daily and normal saline (the vehicle of buserelin) subcutaneously daily. The buserelin control (n=8) received corn oil orally daily and subcutaneous buserelin injection (75?μg/kg) daily. The calcium control (n=8) was supplemented with 1% calcium in drinking water and daily subcutaneous buserelin injection (75?μg/kg). The remaining rats were given daily oral annatto tocotrienol at 60?mg/kg (n=8) or 100?mg/kg (n=8) plus daily subcutaneous buserelin injection (75?μg/kg) (n=8). At the end of the experiment, the rats were euthanized and their blood, tibia, and femur were harvested. Structural changes of the tibial trabecular and cortical bone were examined using X-ray micro-computed tomography. Femoral bone calcium content and biomechanical strength were also evaluated. Results: Annatto tocotrienol at 60 and 100?mg/kg significantly prevented the deterioration of trabecular bone and cortical thickness in buserelin-treated rats ( P <0.05). Both doses of annatto tocotrienol also improved femoral biomechanical strength and bone calcium content in buserelin-treated rats ( P <0.05). The effects of annatto tocotrienol were comparable to calcium supplementation. Conclusion: Annatto tocotrienol supplementation is effective in preventing degeneration of the bone induced by buserelin. Therefore, it is a potential antiosteoporotic agent for men receiving androgen deprivation therapy.
机译：背景：接受雄激素剥夺治疗的患者会继发性腺功能减退，相关的骨质流失和骨折风险增加。已经显示，来自Bixa orellana（annatto）的生育三烯酚可预防经历性腺功能低下的大鼠的骨骼微结构变化。但是，其在预防由于雄激素剥夺疗法引起的骨质流失方面的潜力尚未得到测试。这项研究的目的是使用布塞林蛋白诱导的骨质疏松大鼠模型评估胭脂红生育三烯酚的骨骼保护作用。方法：将36只3个月大的雄性Sprague Dawley大鼠随机分为六组。在研究开始时牺牲基线对照（n = 6）。正常对照组（n = 8）每天皮下注射玉米油（生育三烯酚的载体），每天皮下注射生理盐水（buserelin的载体）。对照品（n = 8）每天口服玉米油，皮下注射buserelin注射剂（75？μg/ kg）。对照钙（n = 8）在饮用水中补充1％的钙，每天皮下注射布塞林（75？μg/ kg）。其余的大鼠每日口服安那托生育三烯酚，剂量分别为60？mg / kg（n = 8）或100？mg / kg（n = 8）以及每天皮下注射铜绿素注射液（75？μg/ kg）（n = 8）。实验结束时，对大鼠实施安乐死，并收集其血液，胫骨和股骨。使用X射线计算机断层扫描检查胫骨小梁和皮质骨的结构变化。还评估了股骨钙含量和生物力学强度。结果：安那托生育三烯酚浓度分别为60和100？mg / kg可以显着预防小叶小骨治疗的大鼠小梁骨和皮质厚度的降低（P <0.05）。两种剂量的安纳托生育三烯酚也可改善经布素林治疗的大鼠的股骨生物力学强度和骨钙含量（P <0.05）。胭脂红生育三烯酚的作用与补充钙相当。结论：安纳托生育三烯酚的补充可有效预防布塞林诱导的骨骼变性。因此，它是接受雄激素剥夺疗法的男性的潜在抗骨质疏松剂。

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