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首页> 外文期刊>Dynamic Chiropractic >Activity of Sansevieria aethiopica (Thunberg) leaf extracts on the planktonic and the biofilm of Candida albicans ATCC 10231
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Activity of Sansevieria aethiopica (Thunberg) leaf extracts on the planktonic and the biofilm of Candida albicans ATCC 10231

机译：盾形紫苏叶提取物在白色念珠菌ATCC 10231的浮游生物膜上的活性

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Increase in resistance ofCandidaspecies to conventional prescribedantifungal agents poses achallenge to health care. This calls for alternative therapies such as the use of antifungal plant extracts. Therefore, the objective of this study was to screenSansevieria aethiopica(Thunberg.) leaf extracts for anti-fungal activity againstCandida albicans. A microbroth dilution method was used to determine the minimum inhibitory concentrations (MICs) and a biofilm enumeration assay was employed to determine the minimum biofilm inhibition concentrations (MBICs) and minimum biofilm eradication concentrations (MBECs) of the extracts. Electron microscopy was used to determine the effects of the extracts on the ultrastructure of the biofilm of the test fungus. Acetone extract had the least effect onC. albicansATCC 10231 with MIC of 3.125 mg/ml. For the extracts, the MBICs and MBECs were higher than the corresponding MICs. The MBEC: MIC and MBIC: MIC were 8: 1 and 2: 1, 4: 1 and 2: 1, and 8: 1 and 8: 1 for acetone, ethanolic and methanolic extracts, respectively. Extract treated cells showed change in the morphology of the cells. Extracts ofS. aethiopicawere able to affect the proliferation of both planktonic and sessile cells ofC. albicans. Isolation and elucidation of the bioactive ingredients and the effects of the active compound onC. albicansstill warrants further investigation.
机译：念珠菌对常规处方抗真菌药的耐药性增加，对医疗保健构成了挑战。这需要替代疗法，例如使用抗真菌植物提取物。因此，本研究的目的是筛选金银花虎耳草提取物对白色念珠菌的抗真菌活性。使用微肉汤稀释法确定最低抑菌浓度（MICs），采用生物膜枚举测定法确定提取物的最低生物膜抑菌浓度（MBICs）和最低生物膜消灭浓度（MBECs）。用电子显微镜确定提取物对测试真菌生物膜超微结构的影响。丙酮提取物对C的影响最小。 Albicans ATCC 10231，MIC为3.125 mg / ml。对于提取物，MBIC和MBEC高于相应的MIC。对于丙酮，乙醇和甲醇提取物，MBEC：MIC和MBIC：MIC分别为8：1和2：1、4：1和2：1，以及8：1和8：1。提取物处理的细胞显示出细胞形态的变化。 S的提取物。 aethiopicawere能够影响C浮游细胞和无柄细胞的增殖。白色的。生物活性成分的分离和阐明以及活性化合物对C的影响。仍然需要进一步调查。

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