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首页> 外文期刊>Dynamic Chiropractic >Antibacterial activity of Datura stramonium against standard and clinical isolate pathogenic microorganisms
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Antibacterial activity of Datura stramonium against standard and clinical isolate pathogenic microorganisms

机译：曼陀罗对标准和临床分离的致病微生物的抗菌活性

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Datura stramonium more commonly known as Jimson weed or thorn apple is a wide growing flowering plant which has been employed by the local community to treat several ailments in Ethiopia. The purpose of the present work was to assess the antibacterial activity of ethanol, methanol, acetone, chloroform and water extracts of Datura stramonium leaf extracts using broth dilution and agar well diffusion methods against human pathogenic bacteria. Chloroform extracts showed the highest zone of inhibition against most of the tested bacterial strains at the concentration of 50 mg/ml. Water extracts are not able to show any zone of inhibition against all tested bacterial strains as compared to other four solvents used for extraction. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined by standard methods. The MIC and MBC results range from 6.25 to 12.5 mg/ml. The present work shows that D. stramonium has maximum antibacterial activity against Staphylococcus aureus (ATCC 25923; 18.2±2.1 mm) in the chloroform extract, while the minimum antibacterial activity was recorded against Escherichia coli clinical isolate (8.2±1.8 mm) (acetone extract). Chloroform extracts showed the highest zone of inhibition against most of the pathogenic bacterial strains tested as compared to the other solvents used for the extraction. In this study, D. stramonium leaf extracts showed considerable antibacterial activity that sustains the local residential area which uses this plant to treat bacterial and fungal infections, hence leading to the conclusion that, this plant would serve as sources of antimicrobial agents to obtain the best treatment alternatives for the infective disease. Further investigation of this potential antibacterial agent is required, especially using chloroform as an extraction solvent to precisely demonstrate the antimicrobial effects of the plant.
机译：曼陀罗的曼陀罗（Datura stramonium）是一种生长广泛的开花植物，当地社区已将其用于治疗埃塞俄比亚的多种疾病。本工作的目的是使用肉汤稀释和琼脂孔扩散方法评估曼陀罗叶提取物的乙醇，甲醇，丙酮，氯仿和水提取物对人病原菌的抗菌活性。在50 mg / ml的浓度下，氯仿提取物对大多数受试细菌菌株显示出最高的抑制区。与用于提取的其他四种溶剂相比，水提取物对所有测试的细菌菌株均无抑制作用。通过标准方法确定最小抑菌浓度（MIC）和最小杀菌浓度（MBC）。 MIC和MBC结果范围为6.25至12.5 mg / ml。目前的工作表明，D.stramonium在氯仿提取物中对金黄色葡萄球菌具有最大的抗菌活性（ATCC 25923; 18.2±2.1 mm），而对大肠杆菌临床分离株的抗菌活性最低（8.2±1.8 mm）（丙酮提取物）。与用于提取的其他溶剂相比，氯仿提取物对测试的大多数病原菌菌株显示出最高的抑制区。在这项研究中，D。stramonium叶提取物显示出显着的抗菌活性，维持了使用该植物治疗细菌和真菌感染的当地居民区，因此得出结论，该植物将作为获得最佳抗菌剂的来源。传染病的替代治疗。需要进一步研究这种潜在的抗菌剂，特别是使用氯仿作为提取溶剂，以精确地证明植物的抗菌作用。

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