The Expression of Serum Antibodies Against Gonadotropin-releasing Hormone (GnRH1), Progonadoliberin-2, Luteinizing Hormone (LH), and Related Receptors in Patients with Gastrointestinal Dysfunction or Diabetes Mellitus

Bodil Roth; Kerstin Berntorp; Bodil Ohlsson

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The Expression of Serum Antibodies Against Gonadotropin-releasing Hormone (GnRH1), Progonadoliberin-2, Luteinizing Hormone (LH), and Related Receptors in Patients with Gastrointestinal Dysfunction or Diabetes Mellitus

机译：胃肠道功能障碍或糖尿病患者抗促性腺激素释放激素（GnRH1），促性腺激素释放素2，黄体生成激素（LH）和相关受体的血清抗体的表达

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Gonadotropin-releasing hormone (GnRH) 1 and 2 and luteinizing hormone (LH) receptors have been described in the gastrointestinal tract. We have previously demonstrated antibodies in serum against GnRH1 in patients with gastrointestinal dysfunction and diabetes mellitus, and antibodies against GnRH receptor, LH, and LH receptor in patients with infertility. The aim of this study was to search for the expression of serum antibodies against GnRH1 with an improved enzyme-linked immune sorbent assay (ELISA), and antibodies against progonadoliberin-2, GnRH2, GnRH receptor, LH, and LH receptor with newly developed ELISAs, in patients with gastrointestinal dysfunction or diabetes mellitus. Healthy blood donors served as controls. Medical records were scrutinized. Our conclusion was that IgM antibodies against GnRH1, progonadoliberin-2, and/or GnRH receptors were more prevalent in patients with functional gastrointestinal disorders, gastrointestinal dysmotility, and/or diabetes mellitus, whereas IgG antibodies against these peptides, and LH- and LH receptor antibodies, were expressed in the same magnitude as in controls.

机译：胃肠道中已经描述了促性腺激素释放激素（GnRH）1和2和黄体生成激素（LH）受体。我们先前已经证明了胃肠功能障碍和糖尿病患者血清中针对GnRH1的抗体，以及不育患者血清中针对GnRH受体，LH和LH受体的抗体。这项研究的目的是通过改进的酶联免疫吸附试验（ELISA）来寻找针对GnRH1的血清抗体的表达，并通过新开发的ELISA来寻找针对progonadoliberin-2，GnRH2，GnRH受体，LH和LH受体的抗体的表达胃肠道功能障碍或糖尿病患者。健康献血者作为对照。检查病历。我们的结论是，针对GnRH1，progonadoliberin-2和/或GnRH受体的IgM抗体在功能性胃肠功能紊乱，胃肠道运动障碍和/或糖尿病患者中更为普遍，而针对这些肽的IgG抗体以及LH-和LH受体抗体的表达量与对照相同。

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《Drug Target Insights》 |2014年第8期|共6页
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Bodil Roth; Kerstin Berntorp; Bodil Ohlsson;
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1. Regulation of gonadotropin-releasing hormone and luteinizing hormone secretion by AMPA receptors. Evidence for a physiological role of AMPA receptors in the steroid-induced luteinizing hormone surge. [J] . Ping L, Mahesh VB, Bhat GK, Neuroendocrinology: International Journal for Basic and Clinical Studies on Neuroendocrine Relationships . 1997,第4期

机译：AMPA受体调节促性腺激素释放激素和促黄体激素分泌。 AMPA受体在类固醇诱导的促黄体激素激增中的生理作用的证据。
2. Is there a Need for Luteinizing Hormone (LH) Estimation in Patients Undergoing Ovarian Stimulation with Gonadotropin-Releasing Hormone (GnRH) Antagonists and Recombinant Follicle-Stimulating Hormone (rFSH)? [J] . Amar Ra machandran, Kshitij Ja mdade, Pratap Kumar, Journal of Clinical and Diagnostic Research . 2014,第1期

机译：在接受促性腺激素释放激素（GnRH）拮抗剂和重组促卵泡激素（rFSH）的卵巢刺激患者中，是否需要估计黄体生成激素（LH）？
3. Effects of long-term treatment with the luteinizing hormone-releasing hormone (LHRH) agonist Decapeptyl and the LHRH antagonist Cetrorelix on the levels of pituitary LHRH receptors and their mRNA expression in rats [J] . Judit E. Horvath, Ana M. Bajo, Andrew V. Schally, Proceedings of the National Academy of Sciences of the United States of America . 2002,第23期

机译：黄体生成素释放激素（LHRH）激动剂Decapeptyl和LHRH拮抗剂Cetrorelix长期治疗对大鼠垂体LHRH受体水平及其mRNA表达的影响
4. 7 Gene-Modified Animal Models for the Study of Luteinizing Hormone and Luteinizing Hormone Receptor Function [C] . F.-P. Zhang, M. Poutanen, I. Huhtaniemi European Workshop on Molecular and Cellular Endocrinology of the Testis . 2002

机译：7基因改性的动物模型，用于研究叶黄素激素和叶黄素激素受体功能
5. Interactions between luteinizing hormone releasing hormone (LHRH), opioid receptors and estrogen in SK-N-SH human neuroblastoma cells. [D] . Bennett, Lunawati Lo. 2002

机译：黄体生成素释放激素（LHRH），阿片样物质受体和雌激素在SK-N-SH人成神经细胞瘤细胞中的相互作用。
6. The Expression of Serum Antibodies Against Gonadotropin-releasing Hormone (GnRH1) Progonadoliberin-2 Luteinizing Hormone (LH) and Related Receptors in Patients with Gastrointestinal Dysfunction or Diabetes Mellitus [O] . Bodil Roth, Kerstin Berntorp, Bodil Ohlsson 2014

机译：胃肠道功能障碍或糖尿病患者抗促性腺激素释放激素（GnRH1）促性腺激素释放素2黄体生成激素（LH）和相关受体的血清抗体的表达
7. The Expression of Serum Antibodies Against Gonadotropin-releasing Hormone (GnRH1), Progonadoliberin-2, Luteinizing Hormone (LH), and Related Receptors in Patients with Gastrointestinal Dysfunction or Diabetes Mellitus. [O] . Roth, Bodil, Berntorp, Kerstin, Ohlsson, Bodil 2014

机译：胃肠道功能障碍或糖尿病患者血清抗体促性腺激素释放激素（GnRH1），progonadoliberin-2，促黄体激素（LH）及相关受体的表达。

The Expression of Serum Antibodies Against Gonadotropin-releasing Hormone (GnRH1), Progonadoliberin-2, Luteinizing Hormone (LH), and Related Receptors in Patients with Gastrointestinal Dysfunction or Diabetes Mellitus

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