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首页> 外文期刊>Drug Target Insights >Vernakalant in Atrial Fibrillation: A Relatively New Weapon in the Armamentarium Against an Old Enemy
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Vernakalant in Atrial Fibrillation: A Relatively New Weapon in the Armamentarium Against an Old Enemy

机译：心房颤动中的Vernakalant：相对于旧敌人的武器库中的一种相对较新的武器。

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Atrial fibrillation is the most common sustained cardiac arrhythmia, and its prevalence is increasing with age; also it is associated with significant morbidity and mortality. Rhythm control is advised in recent-onset atrial fibrillation, and in highly symptomatic patients, also in young and active individuals. Moreover, rhythm control is associated with lower incidence of progression to permanent atrial fibrillation. Vernakalant is a relatively new anti-arrhythmic drug that showed efficacy and safety in recent-onset atrial fibrillation. Vernakalant is indicated in atrial fibrillation (?7?days) in patients with no heart disease (class I, level A) or in patients with mild or moderate structural heart disease (class IIb, level B). Moreover, Vernakalant may be considered for recent-onset atrial fibrillation (?3?days) post cardiac surgery (class IIb, level B). Although it is mainly indicated in patients with recent-onset atrial fibrillation and with no structural heart disease, it can be given in moderate stable cardiac disease as alternative to Amiodarone. Similarly to electrical cardioversion, pharmacological cardioversion requires a minimal evaluation and cardioversion should be included in a comprehensive management strategy for better outcome.
机译：心房颤动是最常见的持续性心律不齐，其患病率随年龄增长而增加。它也与明显的发病率和死亡率有关。建议在近期发作的心房颤动以及症状强烈的患者中，包括年轻和活跃个体中，控制心律。此外，节律控制与进展为永久性房颤的发生率较低相关。 Vernakalant是一种相对较新的抗心律不齐药物，在最近发作的房颤中显示出疗效和安全性。在没有心脏病的患者（I级，A级）或在轻度或中度结构性心脏病的患者（IIb级，B级）的房颤（约7天）中显示了Vernakalant。此外，可考虑将Vernakalant用于心脏手术后最​​近发作的心房纤颤（约3天）（IIb级，B级）。尽管它主要用于近期发作的房颤且无结构性心脏病的患者，但可以在中度稳定的心脏病中代替胺碘酮使用。与电复律类似，药理复律需要最少的评估，而复律应包括在综合治疗策略中以取得更好的疗效。

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