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首页> 外文期刊>Drug Target Insights >The Adaptogens Rhodiola and Schizandra Modify the Response to Immobilization Stress in Rabbits by Suppressing the Increase of Phosphorylated Stress-activated Protein Kinase, Nitric Oxide and Cortisol
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The Adaptogens Rhodiola and Schizandra Modify the Response to Immobilization Stress in Rabbits by Suppressing the Increase of Phosphorylated Stress-activated Protein Kinase, Nitric Oxide and Cortisol

机译：适应原红景天和五味子通过抑制磷酸化应激激活的蛋白激酶，一氧化氮和皮质醇的增加来改变家兔对固定应激的反应。

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Adaptogens possess anti-fatigue and anti-stress activities that can increase mental and physical working performance against a background of fatigue or stress. The aim of the present study was to ascertain which mediators of stress response are significantly involved in the mechanisms of action of adaptogens, and to determine their relevance as biochemical markers for evaluating anti-stress effects in rabbits subjected to restraint stress. Blood levels of stress-activated protein kinase (SAPK/JNK), the phosphorylated kinase p-SAPK/p-JNK, nitric oxide (NO), cortisol, testosterone, prostaglandin E2, leukotriene B4 and thromboxane B2 were determined in groups of animals prior to daily oral administration of placebo, rhodioloside or extracts of Eleutherococcus senticosus, Schizandra chinensis, Rhodiola rosea, Bryonia alba and Panax ginseng over a 7 day period. Ten minutes after the fi nal treatment, animals were immobilized for 2 hours and blood levels of the markers re-determined. In the placebo group, only p-SAPK/p-JNK, NO and cortisol were increased significantly (by 200–300% cf basal levels) following restraint stress, whilst in animals that had received multiple doses of adaptogens/stress-protectors, the levels of NO and cortisol remained practically unchanged after acute stress. Rhodioloside and extracts of S. chinensis and R. rosea were the most active inhibitors of stress-induced p-SAPK/p-JNK. E. senticosus, B. alba and P. ginseng exerted little effect on p-SAPK/p-JNK levels. It is suggested that the inhibitory effects of R. rosea and S. chinensis on p-SAPK/p-JNK activation may be associated with their anti-depressant activity as well as their positive effects on mental performance under stress.
机译：适应原具有抗疲劳和抗压力活动，可在疲劳或压力背景下提高精神和身体工作表现。本研究的目的是确定应激反应的哪些介体显着参与了适应原的作用机制，并确定了它们作为生物化学标记物在评估束缚应激兔抗应激作用中的相关性。在以前的动物组中测定了应激激活蛋白激酶（SAPK / JNK），磷酸化激酶p-SAPK / p-JNK，一氧化氮（NO），皮质醇，睾丸激素，前列腺素E2，白三烯B4和血栓烷B2的血药浓度在7天的时间内每天口服安慰剂，红景天苷或刺五加，五味子，玫瑰红景天，白菜和人参提取物。最终处理十分钟后，将动物固定2小时，然后重新测定标记物的血药浓度。在安慰剂组中，束缚应激后仅p-SAPK / p-JNK，NO和皮质醇显着增加（比基础水平高200-300％cf），而在接受多次剂量的适应原/应激保护剂的动物中，急性应激后，NO和皮质醇的水平几乎保持不变。红景天苷和中华链球菌和玫瑰蔷薇提取物是应激诱导的p-SAPK / p-JNK活性最强的抑制剂。 E. senticosus，B。alba和P.人参对p-SAPK / p-JNK水平几乎没有影响。有人提出玫瑰蔷薇和中华链球菌对p-SAPK / p-JNK活化的抑制作用可能与其抗抑郁活性以及它们在压力下对心理表现的积极作用有关。

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