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首页> 外文期刊>Drug Target Insights >Modulation of Visceral Nociception, Inflammation and Gastric Mucosal Injury by Cinnarizine
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Modulation of Visceral Nociception, Inflammation and Gastric Mucosal Injury by Cinnarizine

机译：桂利嗪对内脏伤害感受，炎症和胃黏膜损伤的调节

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The effect of cinnarizine, a drug used for the treatment of vertigo was assessed in animal models of visceral nociception, inflammation and gastric mucosal injury. Cinnarizine (1.25–20 mg/kg, s.c.) caused dose-dependent inhibition of the abdominal constrictions evoked by i.p. injection of acetic acid by 38.7–99.4%. This effect of cinnarizine (2.5 mg/kg) was unaffected by co-administration of the centrally acting dopamine D2 receptor antagonists, sulpiride, haloperidol or metoclopramide, the peripherally acting D2 receptor antagonist domperidone, but increased by the D2 receptor agonist bromocryptine and by the non-selective dopamine receptor antagonist chlorpromazine. The antinociception caused by cinnarizine was naloxone insenstive, but enhanced by propranolol, atropine and by yohimbine. The antinociceptive effect of cinnarizine was prevented by co-treatment with the adenosine receptor blocker theophylline or by the ATP-sensitive potassium channel (KATP) blocker glibenclamide. Cinnarizine at 2.5 mg/kg reversed the baclofen-induced antinociception. Cinnarizine at 2.5 mg/kg reduced immobility time in the Porsolt’s forced-swimming test by 24%. Cinnarizine inhibited the paw oedema response to carrageenan and reduced gastric mucosal lesions caused by indomethacin in rats. It is suggested that cinnarizine exerts anti-infl ammatory, antinociceptive and gastric protective properties. The mechanism by which cinnarizine modulates pain transmission is likely to involve adenosine receptors and KATP channels.
机译：在内脏伤害感受，炎症和胃黏膜损伤的动物模型中评估了肉桂酸（一种用于治疗眩晕的药物）的效果。肉桂利嗪（1.25–20 mg / kg，皮下注射）对腹腔注射引起的腹部收缩产生剂量依赖性抑制作用。注射乙酸的量为38.7–99.4％。共同给药中枢作用的多巴胺D2受体拮抗剂，舒必利，氟哌啶醇或甲氧氯普胺，外周作用的D2受体拮抗剂多潘立酮不会影响肉桂利嗪（2.5 mg / kg）的这种作用，但D2受体激动剂溴隐隐增高了这种作用非选择性多巴胺受体拮抗剂氯丙嗪。肉桂那嗪引起的抗伤害感受是纳洛酮敏感的，但普萘洛尔，阿托品和育亨宾可增强这种感受。通过与腺苷受体阻滞剂茶碱或ATP敏感性钾通道（KATP）阻断剂格列本脲共同治疗，可防止肉桂那嗪的抗伤害感受作用。 2.5 mg / kg的肉桂利嗪逆转了巴氯芬引起的抗伤害感受。 2.5 mg / kg的肉桂利嗪在Porsolt的强制游泳测试中将不动时间减少了24％。桂那利嗪抑制大鼠对角叉菜胶的水肿反应，并减轻吲哚美辛引起的胃粘膜损伤。提示肉桂利嗪具有抗发炎，抗伤害感受和胃保护的特性。肉桂利嗪调节疼痛传递的机制可能涉及腺苷受体和KATP通道。

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