• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Drug Target Insights >Cytokine, Chemokine and Immune Activation Pathway Profiles in Celiac Disease: An Immune System Activity Screening by Expression Macroarrays
【24h】

Cytokine, Chemokine and Immune Activation Pathway Profiles in Celiac Disease: An Immune System Activity Screening by Expression Macroarrays

机译：乳糜泻中的细胞因子，趋化因子和免疫激活途径的概况：免疫系统活动的筛选通过表达Macroarrays。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The aims of the study were to assess the usefulness of expression macroarrays to determine the pattern of expression of cytokines, chemokines and molecules related to immune system activation pathways, in non-stimulated intact intestinal tissue specimens from patients with active CD (aCD) and on a gluten-free diet (GFD), to compare it with two groups of controls with either normal or altered mucosal architecture, and to establish putative targets for diagnostic markers or therapeutic intervention. We have experienced the lack of sensitivity to detect signal of genes with low level of expression. In spite of that, active CD seems to show a Th1 cytokine pattern, but with signs of Th2 activity. Cytokines such as IL-9, IL-11, IL-21 or MIF might be involved in mucosal inflammation in CD. In GFD, some memory cells and DC’s activity remains, and factors that maintain this remnant activation might be responsible of the fast mucosal response on gluten challenge. STAT3 and STAT5 pathways, and their regulatory molecules SOCS’s may result keys for understanding mucosal inflammation in gut and putative targets for further research.
机译：该研究的目的是评估表达大分子阵列在确定未激活的活性CD（aCD）患者的完整肠组织样本中与免疫系统激活途径相关的细胞因子，趋化因子和分子表达模式的有用性。无麸质饮食（GFD），将其与两组具有正常或改变的粘膜结构的对照组进行比较，并建立诊断标记或治疗干预的假定靶标。我们已经体验到缺乏检测低表达水平基因信号的敏感性。尽管如此，活性CD似乎显示Th1细胞因子模式，但具有Th2活性的迹象。细胞因子如IL-9，IL-11，IL-21或MIF可能与CD的粘膜炎症有关。在GFD中，一些记忆细胞和DC的活性仍然存在，而维持这种残余激活的因素可能是麸质激发时粘膜快速反应的原因。 STAT3和STAT5通路及其调节分子SOCS可能是了解肠道粘膜炎症的关键和可能的靶标，需要进一步研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号