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首页> 外文期刊>Japanese journal of infectious diseases >Clinical Manifestations of Children with Microbiologically Confirmed Pertussis Infection and Antimicrobial Susceptibility of Isolated Strains in a Regional Hospital in Japan, 2008–2012
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Clinical Manifestations of Children with Microbiologically Confirmed Pertussis Infection and Antimicrobial Susceptibility of Isolated Strains in a Regional Hospital in Japan, 2008–2012

机译：2008-2012年日本一家地区医院经微生物学证实的百日咳感染和分离株对细菌敏感的儿童的临床表现

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References(11) Cited-By(3) We conducted a retrospective study in 57 children (median age, 3.5 years; range, 1 month–14.5 years) with microbiologically confirmed pertussis infection over a recent 4-year period in a regional hospital in Japan. We obtained nasal swabs from all patients for Bordetella pertussis isolation as well as performed B. pertussis DNA detection using loop-mediated isothermal amplification (LAMP). Of the 57 cases, 34 (60%) were culture-positive and 57 (100%) were LAMP-positive. The frequency of each symptom was as follows: typical paroxysmal cough for over 14 days, 96% (55/57); paroxysms, 86% (49/57); posttussive vomiting, 33% (19/57); inspiratory whoop, 25% (14/57); and apnea, 12% (7/57). Hospitalization was required in 14 cases (25%), 93% (13/14) of which were aged 1 year. The proportion of patients previously immunized against diphtheria-tetanus-acellular pertussis vaccine (DTaP) was 19% (4/21) in children aged 1 year and 92% (11/12) in children aged ≥10 years. Minimum inhibitory concentrations for 6 antimicrobials (erythromycin, clarithromycin, azithromycin, minocycline, amoxicillin, and sulfamethoxazole/trimethoprim) were measured for 30 isolated strains, and all strains were susceptible to all aforementioned antimicrobials. Thus, an additional pertussis vaccination in older children is necessary, and the current macrolides-based treatment strategy is considered reasonable.
机译：参考文献（11）被引用者（3）我们对最近4年内在微生物学证实的百日咳感染的57名儿童（中位年龄为3.5岁;范围为1个月至14.5岁）进行了回顾性研究。日本。我们从所有患者中获得了鼻拭子，用于百日咳博德特氏菌的分离以及使用环介导的等温扩增（LAMP）进行百日咳博德特氏菌DNA检测。在这57例病例中，有34例（60％）为培养阳性，而57例（100％）为LAMP阳性。每种症状的发生频率如下：典型的阵发性咳嗽持续14天以上，占96％（55/57）;发作，86％（49/57）;咳嗽后呕吐，33％（19/57）;吸气大声，25％（14/57）;和呼吸暂停，占12％（7/57）。 14例（25％）需要住院治疗，其中93％（13/14）年龄小于1岁。小于1岁的儿童先前接受白喉破伤风无细胞百日咳疫苗（DTaP）免疫的患者比例为19％（4/21），≥10岁的儿童为92％（11/12）。测定了30种分离菌株的6种抗微生物剂（红霉素，克拉霉素，阿奇霉素，米诺环素，阿莫西林和磺胺甲恶唑/甲氧苄氨嘧啶）的最小抑菌浓度，所有菌株均对上述所有抗菌剂敏感。因此，在较大的儿童中需要额外的百日咳疫苗接种，并且当前基于大环内酯类的治疗策略被认为是合理的。

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