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首页> 外文期刊>JEOS:RP >An integrated Young interferometer based on UV-imprinted polymer waveguides for label-free biosensing applications
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An integrated Young interferometer based on UV-imprinted polymer waveguides for label-free biosensing applications

机译：基于紫外线印迹聚合物波导的集成式杨氏干涉仪，用于无标签生物传感应用

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摘要

We demonstrate a polymer rib waveguide Young interferometer sensor fabricated by UV-imprinting. An inverted rib waveguide structure was utilized in order to simplify the fabrication process. In this configuration grooves are formed on the under cladding layer by UV-imprinting and core material is spin coated on top to fill the grooves. Glucose water solution was used to characterize the sensor response against ambient refractive index changes. The sensing responses correspond linearly with the refractive index change of glucose solutions with a detection limit of about 10-5. To verify the capability of the polymer sensor for biosensing, an immunoassay was performed with c-reactive protein (CRP) and human CRP specific antibody adsorbed on the waveguide surface as a receptor. The CRP solution in PBS (phosphate buffered saline) buffer with a concentration of 2 μg/ml (16 nM) resulted in an obvious response which was over a couple hundred times of the noise level. Based on these values, a detection limit of about 2.4 pg/mm2 was found for the surface sensing of molecular adsorption. With the proposed waveguide configuration, the fabrication of polymer sensors can be ultimately transferred to roll-to-roll mass production to produce low-cost disposable sensors.
机译：我们演示了通过紫外线压印制造的聚合物肋波导杨氏干涉仪传感器。为了简化制造过程，采用了倒肋式波导结构。在这种构造中，通过UV压印在下覆层上形成凹槽，并且将芯材旋涂在顶部以填充凹槽。葡萄糖水溶液用于表征传感器对环境折射率变化的响应。感测响应与葡萄糖溶液的折射率变化线性对应，检测极限约为10-5。为了验证聚合物传感器的生物传感能力，以c反应蛋白（CRP）和吸附在波导表面的人CRP特异性抗体作为受体进行了免疫测定。浓度为2μg/ ml（16 nM）的PBS（磷酸盐缓冲盐水）缓冲液中的CRP溶液产生明显的响应，其响应强度是噪音水平的数百倍。基于这些值，发现分子吸附的表面检测的检测极限为约2.4 pg / mm2。利用所提出的波导配置，聚合物传感器的制造最终可以转移到卷对卷的批量生产中，以生产低成本的一次性传感器。

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