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Integrated optical waveguide and nanoparticle based label-free molecular biosensing concepts

机译：集成的光波导和基于纳米粒子的无标记分子生物传感概念

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We present our developments on integrated optical waveguide based as well as on magnetic nanoparticle based label-free biosensor concepts. With respect to integrated optical waveguide devices, evanescent wave sensing by means of Mach-Zehnder interferometers are used as biosensing components. We describe three different approaches: a) silicon photonic wire waveguides enabling on-chip wavelength division multiplexing, b) utilization of slow light in silicon photonic crystal defect waveguides operated in the 1.3 μm wavelength regime, and c) silicon nitride photonics wire waveguide devices compatible with on-chip photodiode integration operated in the 0.85 μm wavelength regime. The nanoparticle based approach relies on a plasmon-optical detection of the hydrodynamic properties of magnetic-core/gold-shell nanorods immersed in the sample solution. The hybrid nanorods are rotated within an externally applied magnetic field and their rotation optically monitored. When target molecules bind to the surfaces of the nanorods their hydrodynamic volumes increase, which directly translates into a change of the optical signal. This approach possesses the potential to enable real-time measurements with only minimal sample preparation requirements, thus presenting a promising point-of-care diagnostic system.
机译：我们介绍了基于集成光波导以及基于磁性纳米粒子的无标记生物传感器概念的发展。对于集成的光波导装置，借助于马赫曾德尔干涉仪的e逝波感测被用作生物感测组件。我们描述了三种不同的方法：a）能够实现片上波分复用的硅光子线波导，b）在1.3μm波长范围内工作的硅光子晶体缺陷波导中利用慢光，以及c）兼容的氮化硅光子线波导器件片上光电二极管集成在0.85μm波长范围内工作。基于纳米粒子的方法依赖于浸没在样品溶液中的磁芯/金壳纳米棒的流体动力学特性的等离激元光学检测。混合纳米棒在外部施加的磁场中旋转，并对其旋转进行光学监控。当目标分子结合到纳米棒的表面时，它们的流体动力学体积会增加，这直接转化为光信号的变化。这种方法具有仅需最少的样品制备要求就可以进行实时测量的潜力，从而提供了一种很有前途的即时诊断系统。

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