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首页> 外文期刊>Japanese Journal of Pharmacology >Alteration of Lipid Peroxide and Endogenous Antioxidant Contents in Retina of Streptozotocin-Induced Diabetic Rats: Effect of Vitamin A Administration
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Alteration of Lipid Peroxide and Endogenous Antioxidant Contents in Retina of Streptozotocin-Induced Diabetic Rats: Effect of Vitamin A Administration

机译：链脲佐菌素诱导的糖尿病大鼠视网膜中脂质过氧化物和内源性抗氧化剂含量的改变：维生素A的影响

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References(26) Cited-By(17) Possible involvement of lipid peroxide (LPO) in the occurrence of diabetic retinal lesion was investigated using streptozotocin-induced diabetic rats. Young male Wistar rats weighing 100-150 g were made diabetic by daily intraperitoneal injection of 30 mg/kg streptozotocin (STZ) for 5 days. Five weeks after the termination of STZ-treatment, when animals maintained typical hyperglycemia, the tissue level of LPO, estimated by the thiobarbituric acid method in the presence of 0.5 mM EDTA, was found to be augmented in the kidney. At 7 to 9 weeks after the STZ-treatment, the content of LPO in the retina also exhibited a significant increase, while those in the serum, brain and peripheral nerves showed no alteration. This increment of LPO in the kidney and retina was accompanied by the concomitant reduction of fat-soluble antioxidants determined by the ferric chloride-bipyridyl reaction, and insulin treatment (10 u/rat/day, s.c.) completely eliminated the increased formation of LPO in these organs. When diabetic rats were treated with retinol acetate, which had an inhibitory effect on LPO formation in retinal homogenate, the increase in LPO content was found to be significantly suppressed, especially in the retina. These results suggest that the STZ-induced diabetic state may elicit an increased formation of LPO in the retina and kidney, both of which are known to be main organs having typical diabetic lesions.
机译：参考文献（26）被引用（17）使用链脲佐菌素诱导的糖尿病大鼠研究了脂质过氧化物（LPO）可能参与糖尿病性视网膜病变的发生。通过每天腹膜内注射30 mg / kg链脲佐菌素（STZ）5天，使体重100-150 g的年轻雄性Wistar大鼠成为糖尿病。终止STZ治疗后五周，当动物维持典型的高血糖状态时，发现在0.5 mM EDTA存在下通过硫代巴比妥酸法估计的LPO组织水平增加。 STZ治疗后7至9周，视网膜中LPO的含量也显着增加，而血清，脑和外周神经中LPO的含量未见变化。肾脏和视网膜中LPO的这种增加伴随着由氯化铁-联吡啶反应确定的脂溶性抗氧化剂的减少，胰岛素治疗（10 u /大鼠/天，sc）完全消除了LPO形成的增加。这些器官。当糖尿病大鼠接受醋酸视黄醇治疗时，对视网膜匀浆中的LPO形成具有抑制作用，发现LPO含量的增加被显着抑制，尤其是在视网膜中。这些结果表明，STZ诱导的糖尿病状态可能引起视网膜和肾脏中LPO的形成增加，这两者都是已知的具有典型糖尿病病变的主要器官。

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