...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Japanese Journal of Pharmacology >Protection by Polaprezinc, an Anti-ulcer Drug, Against Indomethacin-Induced Apoptosis in Rat Gastric Mucosal Cells
【24h】

Protection by Polaprezinc, an Anti-ulcer Drug, Against Indomethacin-Induced Apoptosis in Rat Gastric Mucosal Cells

机译：抗溃疡药Polaprezinc对吲哚美辛诱导的大鼠胃粘膜细胞凋亡的保护作用

获取原文
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

References(36) Cited-By(15) Polaprezinc [N−(3−aminopropionyl)−L−histidinato zinc](PZ), an anti−ulcer drug, is a chelate compound consisting of zinc and L−carnosine.PZ has been shown to prevent gastric mucosal injury.In the present study, we investigated the inhibitory effect of PZ on indomethacin(IND)−induced apoptosis in a rat gastric mucosal cell line, RGM1.Pretreatment with PZ suppressed caspase−3 activation and subsequent apoptosis in the cells exposed to 500 μM IND in a dose−dependent manner, and 50 μM PZ exhibited the maximum inhibitory effect.Among PZ subcomponents, zinc but not L−carnosine played a pivotal role in this anti−apoptotic function.PZ did not affect mitochondrial cytochrome c release upstream of caspase−3 activation in the IND−induced apoptotic signal pathway.Treatment with 500 μM IND evidently produced reactive oxygen species(ROS)in RGM1 cells.However, PZ did not scavenge ROS in IND−treated cells.Moreover, N−acetyl−L−cysteine, a potent antioxidant, inhibited ROS generation but did not suppress apoptosis in RGM1 cells exposed to IND.These observations demonstrate a novel pharmacological action of PZ;i.e., that PZ, and in particular its zinc subcomponent, inhibits apoptosis via inhibition of caspase−3 activation but not antioxidant activity.
机译：参考文献（36）被引用的By（15）泊拉普锌[N-（3-氨基丙酰基）-L-组氨酸锌]（PZ）是一种抗溃疡药，是由锌和L-肌肽组成的螯合物。在本研究中，我们研究了PZ对吲哚美辛（IND）诱导的大鼠胃粘膜细胞系RGM1凋亡的抑制作用.PZ预处理可抑制caspase-3活化并随后抑制其凋亡。暴露于500μMIND且剂量依赖性的细胞和50μMPZ表现出最大的抑制作用。在PZ亚组分中，锌而不是L-肌肽在该抗凋亡功能中起关键作用.PZ不影响线粒体细胞色素c在IND诱导的凋亡信号通路中释放caspase-3激活的上游.500μMIND处理显然在RGM1细胞中产生了活性氧（ROS），但是PZ并没有清除IND处理细胞中的ROS。 -乙酰基-L-半胱氨酸，一种有效的抗氧化剂，抑制ROS生成这些观察结果证明了PZ具有新颖的药理作用;即PZ，尤其是其锌亚成分通过抑制caspase-3激活抑制了细胞凋亡，但没有抑制抗氧化剂的活性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号