Biochemical and Histochemical Studies of the Effects of Cerebral Metabolism-Improving Drugs on NADPH Diaphorase Activity in Mouse Brain

Kazunori Ishimura; Kyoji Morita; Masato Tamura; Susumu Kagawa; Yoshihiro Tsuruo

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Biochemical and Histochemical Studies of the Effects of Cerebral Metabolism-Improving Drugs on NADPH Diaphorase Activity in Mouse Brain

机译：生化和组织化学研究脑代谢改善药物对小鼠脑中NADPH心肌黄递酶活性的影响

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References(11) The effects of cerebral metabolism-improving drugs on NADPH diaphorase activity in the mouse brain were studied, and we found that diaphorase activity in the post-mitochondrial fraction of brain homogenate was enhanced by idebenone in a concentration-dependent manner. Histochemical studies also indicated that diaphorase staining was intensified by idebenone at the same concentration. These results suggest that idebenone may stimulate the production of nitric oxide, probably through its direct action on nitric oxide synthase, thus producing its protective action on neurological disorders due to cerebral hypoxia or ischemia as a consequence of dilating the cerebral blood vessels.

机译：参考文献（11）研究了脑代谢改善药物对小鼠脑中NADPH心肌黄递酶活性的影响，发现艾地苯醌以浓度依赖的方式增强了脑匀浆线粒体后部分中的心肌黄递酶活性。组织化学研究还表明，相同浓度的艾地苯醌能使心肌黄递酶染色增强。这些结果表明，艾地苯醌可能通过其对一氧化氮合酶的直接作用而刺激一氧化氮的产生，从而在其由于扩张脑血管而导致的脑缺氧或局部缺血而对神经系统疾病中产生保护作用。

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《Japanese Journal of Pharmacology》 |1994年第3期|共4页
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Kazunori Ishimura; Kyoji Morita; Masato Tamura; Susumu Kagawa; Yoshihiro Tsuruo;
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中图分类药理学;
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1. Effects of Flavonoid Compounds on the Activity of NADPH Diaphorase Prepared from the Mouse Brain [J] . Kazunori Ishimura, Kyoji Morita, Masato Tamura, Japanese Journal of Pharmacology . 1994,第4期

机译：黄酮类化合物对小鼠脑中NADPH心肌黄递酶活性的影响
2. Evolutionary significance of different neurochemical organisation of the internal and external regions of auditory centres in the reptilian brain: an immunocytochemical and reduced NADPH-diaphorase histochemical study in turtles. [J] . Belekhova MG, Kenigfest-Rio NB, Vesselkin NP, Brain research . 2002,第1期

机译：爬行动物听觉中心的内部和外部区域的不同神经化学组织的进化意义：乌龟的免疫细胞化学和减少的NADPH-黄递酶组织化学研究。
3. Evidence for increased nitric oxide production in the auditory brain stem of the aged dwarf hamster (Phodopus sungorus): an NADPH-diaphorase histochemical study. [J] . Reuss S, Schaeffer DF, Laages MH, Mechanisms of Ageing and Development . 2000,第2期

机译：老年侏儒仓鼠（Phodopus sungorus）的听觉脑干中一氧化氮产生增加的证据：NADPH-黄递酶的组织化学研究。
4. Diffuse Nerve Net of Hydra Revealed by NADPH-Diaphorase Histochemical Labeling [C] . Luigia Cristino, Vittorio Guglielmotti, Carlo Musio, International Symposium on Advances in Brain, Vision, and Artificial Intelligence(BVAI 2007); 20071010-12; Naples(IT) . 2007

机译：NADPH-心肌酶组织化学标记揭示九头蛇的弥散神经网
5. ESTERASES AND PHOSPHATASES OF ADULT AND DEVELOPING MOUSE BRAIN: A HISTOCHEMICAL STUDY OF ENZYMES SEPARATED BY ZONE ELECTROPHORESIS IN STARCH GEL. [D] . LEMKEY, NAOMI FRIEDA MARGARET. 1962

机译：成年小鼠和正在发育的小鼠脑中的酯酶和磷酸酯酶：淀粉凝胶中区带电泳分离的酶的组织化学研究。
6. Histochemical Characterization Distribution and Morphometric Analysis of NADPH Diaphorase Neurons in the Spinal Cord of the Agouti [O] . Marco Aurélio M. Freire, Suzane C. Tourinho, Joanilson S. Guimarães, 2008

机译：刺痛小鼠脊髓中NADPH重氮酶神经元的组织化学特征分布及形态计量学分析
7. Biochemical and Histochemical Studies of the Effects of Cerebral Metabolism-Improving Drugs on NADPH Diaphorase Activity in Mouse Brain. [O] . Yoshihiro Tsuruo, Kazunori Ishimura, Masato Tamura, 1994

机译：脑代谢改善药物对小鼠脑中NADPH氮素酶活性的影响的生化和组织化学研究。

Biochemical and Histochemical Studies of the Effects of Cerebral Metabolism-Improving Drugs on NADPH Diaphorase Activity in Mouse Brain

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