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首页> 外文期刊>Japanese Journal of Pharmacology >Calcium Is Essential for ATP-Induced Steroidogenesis in Bovine Adrenocortical Fasciculata Cells
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Calcium Is Essential for ATP-Induced Steroidogenesis in Bovine Adrenocortical Fasciculata Cells

机译：钙对于牛肾上腺束状细胞中ATP诱导的类固醇生成至关重要。

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References(20) Cited-By(9) The effect of extracellular ATP on steroidogenesis in primary cultured bovine adrenocortical fasciculata cells was investigated. I observed that in the presence of extracellular Ca2+, ATP caused a dose-dependent elevation of intracellular Ca2+ ([Ca2+]i) and induced steroidogenesis concentration- and time-dependently. However, in the absence of extracellular Ca2+, ATP had no effect on steroidogenesis. In the presence of extracellular Ca2+, calmodulin inhibitors inhibited the ATP-induced steroidogenesis, but dihydropyridine calcium channel blockers did not. Furthermore, ATP did not cause an elevation of cyclic AMP in bovine adrenocortical fasciculata cells even if extracellular Ca2+ existed. These results suggest that extracellular ATP might have an influence on bovine adrenocortical cells via the purinoceptor (P2Y) in connection with calcium mobilization, open the non-selective calcium channel and induce steroidogenesis by means of an elevation of [Ca2+]i via the calcium-calmodulin system.
机译：参考文献（20）被引用的文献（9）研究了细胞外ATP对原代培养的牛肾上腺束状细胞中类固醇生成的影响。我观察到，在细胞外Ca2 +存在的情况下，ATP引起细胞内Ca2 +（[Ca2 +] i）的剂量依赖性升高，并诱导甾体生成浓度和时间依赖性。但是，在不存在细胞外Ca2 +的情况下，ATP对类固醇生成没有影响。在细胞外Ca2 +存在的情况下，钙调蛋白抑制剂可抑制ATP诱导的类固醇生成，但二氢吡啶类钙通道阻滞剂则不能。此外，即使存在细胞外Ca2 +，ATP也不会引起牛肾上腺皮质束细胞中环AMP的升高。这些结果表明，细胞外ATP可能与钙动员有关，通过嘌呤受体（P2Y）对牛肾上腺皮质细胞产生影响，打开非选择性钙通道，并通过钙（Ca2 +）i升高而诱导类固醇生成。钙调蛋白系统。

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