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首页> 外文期刊>Japanese Journal of Pharmacology >Dynorphin-(1-13): Antinociceptive Action and Its Effects on Morphine Analgesia and Acute Tolerance
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Dynorphin-(1-13): Antinociceptive Action and Its Effects on Morphine Analgesia and Acute Tolerance

机译：强啡肽-（1-13）：镇痛作用及其对吗啡镇痛和急性耐受的影响

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References(38) Cited-By(6) Antinociceptive actions and effects of intracerebroventricular (i.c.v.) dynorphin-(1-13) (DYN) on morphine (MOR) analgesia and acute tolerance were studied in male Sprague-Dawley rats. Antinociceptive effect against hind paw pressure was produced by 30 μg of DYN, but not by 0.5-10 μg. Acetic acid writhing was inhibited dose-dependently by DYN at the doses of 2-30 μg, and the order of potency of the anti-writhing effect was β-endorphin MOR DYN Met-enkephalin. The anti-writhing effect of DYN that was partially antagonized by naloxone at 10 mg/kg, s.c. in MOR tolerant rats was the same as that in MOR naive rats. The anti-writhing effect of i.c.v.-MOR was increased synergistically by DYN. Continuous s.c. (6 mg/kg/hr) and i.c.v. (7.5 μg/rat/hr) infusion of MOR produced antinociception against hind paw pressure, which reached maximum (MAX) and attenuated thereafter during MOR infusion for 6 hr. The attenuation of antinociception was also produced during MOR infusion combined with multiple i.c.v.-injection of DYN. The MAX and area under the anti-nociceptive curve during MOR infusion was not affected by multiple injection of DYN, i.e., no effect of i.c.v.-DYN on the development of acute MOR tolerance induced by s.c.- and i.c.v.-infusion was observed. In conclusion, the anti-writhing effect of i.c.v.-DYN might not be mediated via mu-receptors, although DYN increased the anti-writhing effect of i.c.v.-MOR synergistically and the development of acute tolerance to MOR (i.c.v., s.c.) was not affected by i.c.v.-DYN.
机译：参考文献（38）被引用的By（6）对雄性Sprague-Dawley大鼠的镇痛作用以及脑室内（i.c.v.）强啡肽（1-13）（DYN）对吗啡（MOR）镇痛和急性耐受的影响进行了研究。 30克DYN产生了抗后足痛的镇痛作用，但0.5到10克则没有。在2-30μg的剂量下，乙酸扭体被DYN剂量依赖性地抑制，抗扭体作用的效力顺序为β-内啡肽> MOR> DYN> Met-脑啡肽。 DYN的抗扭绞作用被纳洛酮以10 mg / kg的剂量部分拮抗，皮下注射。耐MOR的大鼠与未接受MOR的大鼠相同。 DYN协同增强了i.c.v.-MOR的抗扭曲作用。连续s.c. （6 mg / kg / hr）和i.c.v. （7.5μg/大鼠/小时）的MOR输注产生了针对后爪压力的止痛作用，其达到最大值（MAX），此后在MOR输注6 hr时减弱。在MOR输注和多次DYN静脉注射相结合的过程中，抗伤害感受的减弱也产生了。输注DYN不会影响MOR输注期间抗伤害感受曲线下的MAX和面积，即观察到i.c.v.-DYN对经s.c.-和i.c.v.输注诱导的急性MOR耐受性的发展没有影响。总之，尽管DYN协同增加了icv-MOR的抗扭扭作用并且对MOR（icv，sc）的急性耐受性的发展没有受到影响，但icv-DYN的抗扭扭作用可能不是通过mu受体介导的。由icv-DYN。

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