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首页> 外文期刊>Japanese Journal of Pharmacology >Inhibition of Electrically-Induced Vocalization in Adjuvant Arthritic Rats as a Novel Method for Evaluating Analgesic Drugs
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Inhibition of Electrically-Induced Vocalization in Adjuvant Arthritic Rats as a Novel Method for Evaluating Analgesic Drugs

机译：抑制电诱导的佐剂关节炎大鼠发声作为评价镇痛药的一种新方法

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References(29) Cited-By(16) A new method for the evaluation of analgesic drugs in normal rats and in rats with hyperalgesia induced by adjuvant was developed using the vocalization response as an indicator of pain due to electrical shock. It was demonstrated that at ED50 doses, nonsteroidal anti-inflammatory drugs (NSAIDs), narcotic analgesic drugs and narcotic agonist/antagonist type analgesic drugs were effective, but pure narcotic antagonist drugs, CNS-acting drugs and anti-inflammatory steroid were ineffective. Acidic NSAIDs, except aspirin, were more effective in adjuvant arthritic rats than normals but other analgesic drugs had roughly the same effect in both. It was suggested that the acidic NSAIDs specifically inhibit inflammatory pain. Moreover, the vocalization response under adjuvant treatment is useful for the quantitative measurement of analgesics.
机译：参考文献（29）Cited-By（16）使用发声反应作为电击所致疼痛的指标，开发了一种评估正常大鼠和佐剂引起的痛觉过敏大鼠镇痛药物的新方法。结果表明，在ED50剂量下，非甾体类抗炎药（NSAIDs），麻醉性镇痛药和麻醉性激动剂/拮抗剂型镇痛药是有效的，而纯麻醉药拮抗药，CNS作用药和抗炎类固醇则无效。除阿司匹林外，酸性非甾体类抗炎药在佐剂性关节炎大鼠中比正常人更有效，但其他镇痛药在两者中具有大致相同的作用。有人提出，酸性NSAIDs可以特异性抑制炎症性疼痛。而且，在辅助治疗下的发声反应对于止痛药的定量测量是有用的。

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