Quantitative Analysis of the Ultrasonic Vocalization Responses Elicited in Adjuvant-Induced Arthritic Rats for Screening Analgesic Drugs

Hiroyuki NAITO; Maki INOUE

首页> 外文期刊>Experimental Animals >Quantitative Analysis of the Ultrasonic Vocalization Responses Elicited in Adjuvant-Induced Arthritic Rats for Screening Analgesic Drugs

【24h】

Quantitative Analysis of the Ultrasonic Vocalization Responses Elicited in Adjuvant-Induced Arthritic Rats for Screening Analgesic Drugs

机译：佐剂诱导的关节炎大鼠筛选镇痛药时超声发声反应的定量分析

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Adjuvant-induced arthritic (AIA) rats have been developed as a chronic pain model to evaluate the effects of analgesic drugs. The purpose of the present study was to examine whether there is dose-dependent inhibition of the emission of ultrasonic vocalization (USV) responses by analgesic drugs in AIA rats. It was demonstrated that morphine (1.25-5.0 mg/ kg, s.c.) and ketoprofen (2.5-10.0 mg/kg, s.c.) dose-dependently inhibit USV responses. These results suggest that the USV responses elicited in AIA rats are useful for the quantitative evaluation of analgesic drugs.

机译：佐剂诱发的关节炎（AIA）大鼠已被开发为一种慢性疼痛模型，用于评估镇痛药的作用。本研究的目的是检查在AIA大鼠中镇痛药是否对超声波发声（USV）反应的发射具有剂量依赖性抑制作用。已证明吗啡（1.25-5.0 mg / kg，s.c.）和酮洛芬（2.5-10.0 mg / kg，s.c.）剂量依赖性抑制USV反应。这些结果表明在AIA大鼠中引起的USV反应可用于定量评估止痛药。

著录项

来源
《Experimental Animals》 |2008年第4期|419-422|共4页
作者
Hiroyuki NAITO; Maki INOUE;
展开▼
作者单位

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类
关键词
adjuvant-induced arthritic rats; ketoprofen; morphine; naltrexone; ultrasonic vocalization;

机译：佐剂诱发的关节炎大鼠;酮洛芬吗啡;纳曲酮超声波发声;

相似文献

外文文献
中文文献
专利

1. Ultrasonic Vocalization Response Elicited in Adjuvant-induced Arthritic Rats as a Useful Method for Evaluating Analgesic Drugs [J] . Hiroyuki NAITO, Takako OKUMURA, Maki INOUE, Experimental Animals . 2006,第2期

机译：超声诱发的关节炎大鼠发声反应作为评价镇痛药的有用方法
2. Quantitative gait analysis as a method to assess mechanical hyperalgesia modulated by disease-modifying antirheumatoid drugs in the adjuvant-induced arthritic rat [J] . Shabana Usman Simjee, Huma Jawed, Javeria Quadri, Arthritis Research . 2007,第5期

机译：定量步态分析作为评估佐剂诱导的关节炎大鼠中疾病修饰抗类风湿药调节的机械性痛觉过敏的方法
3. Inhibition of Electrically-Induced Vocalization in Adjuvant Arthritic Rats as a Novel Method for Evaluating Analgesic Drugs [J] . Hironaka AIHARA, Shigeru OKUYAMA Japanese Journal of Pharmacology . 1984,第1期

机译：抑制电诱导的佐剂关节炎大鼠发声作为评价镇痛药的一种新方法
4. Quantitative Research on Analgesic Effects of Electroacupuncture at Multiple Factors Parameters in Rats of Adjuvant-Induced Arthritis [C] . Le Kuai, Huayuan Yang, Jie Jiang 7th Asian-Pacific Conference on Medical and Biological Engineering（第七届亚太地区生物工程学术会议）论文集 . 2008

机译：电针对佐剂性关节炎大鼠多因素参数镇痛作用的定量研究。
5. The development and application of quantitative structure-activity relationship and classification techniques for virtual screening in drug design. [D] . Sutherland, Jeffrey J. 2004

机译：药物设计中虚拟筛选的定量构效关系和分类技术的开发和应用。
6. Quantitative gait analysis as a method to assess mechanical hyperalgesia modulated by disease-modifying antirheumatoid drugs in the adjuvant-induced arthritic rat [O] . Shabana Usman Simjee, Huma Jawed, Javeria Quadri, 2007

机译：定量步态分析作为评估佐剂诱导的关节炎大鼠中疾病修饰抗类风湿药调节的机械性痛觉过敏的方法
7. Quantitative gait analysis as a method to assess mechanical hyperalgesia modulated by disease-modifying antirheumatoid drugs in the adjuvant-induced arthritic rat [O] . 2007

机译：定量步态分析作为评估佐剂诱导的关节炎大鼠中疾病修饰抗类风湿药调节的机械性痛觉过敏的方法

Quantitative Analysis of the Ultrasonic Vocalization Responses Elicited in Adjuvant-Induced Arthritic Rats for Screening Analgesic Drugs

摘要

著录项

相似文献

相关主题

期刊订阅