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首页> 外文期刊>Japanese Journal of Pharmacology >Pharmacological Studies on Lappaconitine: Antinociception and Inhibition of the Spinal Action of Substance P and Somatostatin
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Pharmacological Studies on Lappaconitine: Antinociception and Inhibition of the Spinal Action of Substance P and Somatostatin

机译：拉帕卡尼汀的药理研究：P物质和生长抑素的脊髓损伤作用的抗伤害感受和抑制作用

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References(36) Cited-By(9) The pain response of mice to an injection of 0.5% formalin into the dorsal surface of a hindpaw is biphasic, with a first phase lasting for 5 min and a second phase lasting from 10 to 30 min post-injection. Intrathecal (i.t.) injection of [D-Pro2, D-Trp7, 9]-substance P inhibited the first phase, and i.t. cysteamine inhibited the second phase. Lappaconitine (LA) and morphine (MOR) inhibited both phases equally in a dose-dependent manner. Diclofenac inhibited both phases, but the second phase was inhibited by lower doses. An Lt. injection of substance P (SP) or somatostatin (SOM) produced a characteristic behavioral response (scratching, biting, and licking). This behavioral response to SP and SOM was inhibited by s.c., intracerebroventricular (i.c.v.), or Lt. injection of MOR. In contrast, LA inhibited the SP and SOM-induced response when injected s.c. or i.c.v., but had no effect when injected intrathecally. These results indicate that LA may act supraspinally to inhibit the transmission of nociceptive information by SP and/or SOM.
机译：参考文献（36）被引（9）（By）（9）小鼠向后爪背表面注射0.5％福尔马林的疼痛反应是双相的，第一阶段持续5分钟，第二阶段持续10至30分钟注射后。鞘内（i.t.）注射[D-Pro2，D-Trp7、9]物质P抑制了第一相，而i.t.半胱胺抑制第二阶段。拉帕卡尼汀（LA）和吗啡（MOR）以剂量依赖性方式均等地抑制两个阶段。双氯芬酸抑制两个阶段，但第二阶段被较低剂量抑制。长期注射物质P（SP）或生长抑素（SOM）会产生特征性的行为反应（抓挠，咬和舔）。对SP和SOM的这种行为反应被皮下注射，脑室内（i.c.v.）或Lt注射MOR抑制。相反，当皮下注射时，LA抑制SP和SOM诱导的反应。或i.c.v.，但鞘内注射无效。这些结果表明，LA可能在脊髓上起作用，以抑制SP和/或SOM传递伤害性信息。

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