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首页> 外文期刊>JMIR public health and surveillance. >Adverse Reactions Associated With Cannabis Consumption as Evident From Search Engine Queries
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Adverse Reactions Associated With Cannabis Consumption as Evident From Search Engine Queries

机译：从搜索引擎查询中明显看出，与大麻消费有关的不良反应

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Background: Cannabis is one of the most widely used psychoactive substances worldwide, but adverse drug reactions (ADRs) associated with its use are difficult to study because of its prohibited status in many countries. Objective: Internet search engine queries have been used to investigate ADRs in pharmaceutical drugs. In this proof-of-concept study, we tested whether these queries can be used to detect the adverse reactions of cannabis use. Methods: We analyzed anonymized queries from US-based users of Bing, a widely used search engine, made over a period of 6 months and compared the results with the prevalence of cannabis use as reported in the US National Survey on Drug Use in the Household (NSDUH) and with ADRs reported in the Food and Drug Administration’s Adverse Drug Reporting System. Predicted prevalence of cannabis use was estimated from the fraction of people making queries about cannabis, marijuana, and 121 additional synonyms. Predicted ADRs were estimated from queries containing layperson descriptions to 195 ICD-10 symptoms list. Results: Our results indicated that the predicted prevalence of cannabis use at the US census regional level reaches an R 2 of .71 NSDUH data. Queries for ADRs made by people who also searched for cannabis reveal many of the known adverse effects of cannabis (eg, cough and psychotic symptoms), as well as plausible unknown reactions (eg, pyrexia). Conclusions: These results indicate that search engine queries can serve as an important tool for the study of adverse reactions of illicit drugs, which are difficult to study in other settings.
机译：背景：大麻是世界上使用最广泛的精神活性物质之一，但由于其在许多国家被禁止使用，因此与其使用相关的不良药物反应（ADR）很难研究。目的：互联网搜索引擎查询已用于调查药品中的ADR。在此概念验证研究中，我们测试了这些查询是否可用于检测大麻使用的不良反应。方法：我们分析了来自美国的Bing（一个广泛使用的搜索引擎）在6个月内进行的匿名查询，并将结果与​​《美国全国家庭用药调查》中报告的大麻使用率进行了比较。 （NSDUH）和ADR在食品和药物管理局的不良药品报告系统中报告。根据对大麻，大麻和121种其他同义词的询问的比例，估计了大麻使用的流行率。通过对包含195个ICD-10症状列表的外行描述进行查询，可以估算出预期的ADR。结果：我们的结果表明，在美国人口普查区域一级，大麻使用的预测流行率达到2.71 NSDUH数据的R 2。对也搜索大麻的人进行的ADR查询显示，大麻存在许多已知的不良影响（例如咳嗽和精神病性症状），以及可能出现的未知反应（例如发热）。结论：这些结果表明，搜索引擎查询可以作为研究非法药物不良反应的重要工具，而在其他情况下则难以研究。

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