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首页> 外文期刊>Jornal Brasileiro de Patologia e Medicina Laboratorial >Immunohistochemical study of macrophages subpopulations associated with squamous cell carcinoma of the tongue, with and without metastasis
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Immunohistochemical study of macrophages subpopulations associated with squamous cell carcinoma of the tongue, with and without metastasis

机译：伴或不伴转移的舌鳞状细胞癌相关巨噬细胞亚群的免疫组织化学研究

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ABSTRACT Introduction: Stromal cells interact with tumor cells and play an important role in cancer invasion and metastasis. Tumor-associated macrophages (TAMs) can exhibit M1 phenotype, important immune effector cells, or M2 phenotype, able to suppress the function of M1 macrophages and influence angiogenesis and tissue repair. The CD68 antibody recognizes M1 and M2 macrophages, whereas CD163 antibody is specific only to identify M2 macrophages. Objective: To investigate the presence of TAMs in a number of cases squamous cell carcinoma (SCC) of the tongue by associating it with the occurrence of metastasis. Material and methods: Immunohistochemistry was used to evaluate the immunopositivity for CD68 and CD163 in 27 cases of SCC of the tongue. Results: The percentage of CD68 positive macrophages was higher than CD163 positive macrophages in all specimens studied. Comparing CD163 and CD68 immunostaining in the studied groups, it was observed that cases without metastasis had a higher percentage of CD68 positive cells in relation to CD163 positive cells, which was statistically significant. Conclusion: Considering these results, there was a predominance of M1 macrophages in SCC of the tongue cases without metastasis, suggesting the influence of these cells in clinical behavior of the lesion.
机译：摘要简介：基质细胞与肿瘤细胞相互作用，并在癌症的侵袭和转移中发挥重要作用。肿瘤相关巨噬细胞（TAM）可以表现出M1表型，重要的免疫效应细胞或M2表型，能够抑制M1巨噬细胞的功能并影响血管生成和组织修复。 CD68抗体识别M1和M2巨噬细胞，而CD163抗体仅特异性识别M2巨噬细胞。目的：通过将其与转移的发生联系起来，研究许多病例的舌鳞状细胞癌（SCC）中TAM的存在。材料与方法：采用免疫组织化学方法对27例舌鳞癌中CD68和CD163的免疫阳性进行评估。结果：在所有研究样本中，CD68阳性巨噬细胞的百分比高于CD163阳性巨噬细胞的百分比。比较研究组中的CD163和CD68免疫染色，观察到没有转移的病例相对于CD163阳性细胞，CD68阳性细胞的百分比更高，这在统计学上是显着的。结论：考虑到这些结果，在没有转移的舌癌病例中，M1巨噬细胞占优势，表明这些细胞对病变临床行为的影响。

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