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首页> 外文期刊>Journal of Acupuncture and Meridian Studies >Effects of Acupuncture at Zu-San-Li (ST36) on the Activity of the Hypothalamic–Pituitary–Adrenal Axis during Ethanol Withdrawal in Rats
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Effects of Acupuncture at Zu-San-Li (ST36) on the Activity of the Hypothalamic–Pituitary–Adrenal Axis during Ethanol Withdrawal in Rats

机译：针刺足三里穴（ST36）对大鼠戒断乙醇时下丘脑-垂体-肾上腺轴活性的影响

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The current study investigated the effects of acupuncture at Zu-San-Li (ST36) on the hypothalamic–pituitary–adrenal axis during ethanol withdrawal in rats. Rats were intraperitoneally treated with 3?g/kg/day of ethanol or saline for 28 days. Following 24 hours of ethanol withdrawal, acupuncture was applied at bilateral ST36 points or non-acupoints (tail) for 1 minute. Plasma levels of corticosterone (CORT) and adrenocorticotropic hormone (ACTH) were measured by radioimmunoassay (RIA), and the corticotropin-releasing factor (CRF) protein levels in the paraventricular nucleus of the hypothalamus were also examined by RIA 20 minutes after the acupuncture treatment. RIA showed significantly increased plasma levels of CORT and ACTH in the ethanol-withdrawn rats compared with the saline-treated rats, which were inhibited significantly by the acupuncture at the acupoint ST36 but not at the non-acupoint. Additionally, ethanol withdrawal promoted CRF protein expressions in the paraventricular nucleus of the hypothalamus, which were also blocked by the acupuncture at ST36. These findings suggest that acupuncture at the specific acupoint ST36 can inhibit ethanol withdrawal-induced hyperactivation of hypothalamic–pituitary–adrenal axis, and it may be mediated via the modulation of hypothalamic CRF.
机译：目前的研究调查了针刺足三里（ST36）对大鼠乙醇戒断过程中下丘脑-垂体-肾上腺轴的影响。用3μg/ kg /天的乙醇或盐水腹膜内处理大鼠28天。撤除乙醇24小时后，在双侧ST36点或非穴位（尾巴）针刺1分钟。针刺治疗20分钟后，通过放射免疫法（RIA）测定血浆皮质激素（CORT）和促肾上腺皮质激素（ACTH）的水平，并通过RIA检查下丘脑室旁核中促肾上腺皮质激素释放因子（CRF）蛋白的水平。 。与盐水处理的大鼠相比，RIA显示撤除乙醇的大鼠血浆中CORT和ACTH的血浆水平显着增加，针刺在ST36穴位显着抑制，而在非穴位则没有。此外，乙醇戒断促进了下丘脑室旁核中CRF蛋白的表达，这也被ST36的针刺所阻断。这些发现表明，在特定的穴位ST36进行针刺可以抑制乙醇戒断所引起的下丘脑-垂体-肾上腺轴的过度活化，这可能是通过调节下丘脑CRF介导的。

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