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首页> 外文期刊>Jornal Brasileiro de Patologia e Medicina Laboratorial >Lymphangiogenesis: from the pig embryos to cancer
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Lymphangiogenesis: from the pig embryos to cancer

机译：淋巴管生成：从猪胚胎到癌症

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The discovery and the comprehension of lymphatic vessels suffered several historical delays and setbacks. The inherent anatomical problems slowed down the precise identification of the lymphatic system during the development of medical science. Gasparo Aselli, an Italian surgeon and anatomist, was the first to describe the lymphatic vessels in 1627 (De Lacteibus sive Lacteis Venis). However, most original descriptions that report the morphology of the lymphatic system in different organisms were done during the 19th and the 20th centuries. The recent identification of specific lymphatic vasculature molecular markers allows a more accurate identification and characterization of the lymphatic system evolution in different organs, as well as its role in different pathological conditions, including cancer. This study summarizes the current understanding of lymphangiogenesis in tumour progression, as well as it presents a review of the promising data regarding the prognostic value of lymphatic density and the use of therapeutic lymphangiogenic molecules.
机译：淋巴管的发现和理解经历了一些历史性的延误和挫折。在医学科学发展过程中，固有的解剖学问题减慢了淋巴系统的精确识别。意大利外科医生和解剖学家加斯帕洛·阿斯利（Gasparo Aselli）最早在1627年描述了淋巴管（De Lacteibus sive Lacteis Venis）。但是，大多数报道不同生物中淋巴系统形态的原始描述是在19世纪和20世纪进行的。最近对特定的淋巴管系统分子标记物的鉴定可以更准确地鉴定和表征不同器官中的淋巴系统进化，以及其在包括癌症在内的不同病理状况中的作用。这项研究总结了目前对肿瘤进展中淋巴管生成的理解，并提出了关于淋巴密度的预后价值和治疗性淋巴管生成分子的应用的有希望的数据的综述。

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