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首页> 外文期刊>Journal of Advanced Pharmaceutical Technology Research >Effect of bioadhesion on initial in vitro buoyancy of effervescent floating matrix tablets of ciprofloxacin HCL
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Effect of bioadhesion on initial in vitro buoyancy of effervescent floating matrix tablets of ciprofloxacin HCL

机译：生物粘附力对盐酸环丙沙​​星泡腾片悬浮泡腾片体外浮力的影响

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The purpose of this study was to investigate effect of bioadhesion on the initial in vitro buoyancy behaviour of effervescent matrix tablets of ciprofloxacin HCl (CIPRO). Tablets were prepared by direct compression using HPMC K4M and Carbopol 971P as hydrophilic-controlled release polymers, sodium bicarbonate (NaHCO3) as gas-generating agent, polyplasdone XL, Explotab and Ac-Di-Sol as swelling agents. Tablets were evaluated for normal and modified initial in vitro floating behavior, floating duration, swelling behavior and in vitro drug release studies. A modified buoyancy lag time for tablets was determined in order to include the effect of bioadhesion on initial buoyancy. The initial buoyancy was found depended on bioadhesion ability of tablets. The lowest modified buoyancy lag time of 20 seconds was obtained for Formulation F7 having both NaHCO3 and polyplasdone XL. The floating duration was also found dependent on concentration of NaHCO3 and swelling agents. The drug release of F7 was also sustained up to 12-hr duration with anomalous drug transport mechanism.Keywords: Bioadhesion, effervescent matrix tablets, gastroretention, modified buoyancy lag time, swelling agents
机译：这项研究的目的是调查生物粘附力对盐酸环丙沙​​星泡腾片的初始体外浮力行为的影响。通过使用HPMC K4M和Carbopol 971P作为亲水性控释聚合物，碳酸氢钠（NaHCO3）作为气体发生剂，聚普拉斯酮XL，Explotab和Ac-Di-Sol作为溶胀剂进行直接压片来制备片剂。评价片剂的正常和改良的初始体外漂浮行为，漂浮持续时间，溶胀行为和体外药物释放研究。确定了片剂的改进的浮力滞后时间，以包括生物粘附力对初始浮力的影响。发现初始浮力取决于片剂的生物粘附能力。对于同时具有NaHCO3和聚普拉斯酮XL的配方F7，获得的最低改性浮力滞后时间为20秒。还发现漂浮持续时间取决于NaHCO 3和溶胀剂的浓度。 F7的药物释放也可以持续长达12小时，并且具有异常的药物转运机制。关键词：生物粘附，泡腾片，胃滞留，改良的浮力滞后时间，溶胀剂

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