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首页> 外文期刊>Journal of Animal Science and Biotechnology >miRNA-dysregulation associated with tenderness variation induced by acute stress in Angus cattle
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miRNA-dysregulation associated with tenderness variation induced by acute stress in Angus cattle

机译：与安格斯牛急性应激诱导的压痛变化相关的miRNA调节异常

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miRNAs are a class of small, single-stranded, non-coding RNAs that perform post-transcriptional repression of target genes by binding to 3’ untranslated regions. Research has found that miRNAs involved in the regulation of many metabolic processes. Here we uncovered that the beef quality of Angus cattle sharply diversified after acute stress. By performing miRNA microarray analysis, 13 miRNAs were significantly differentially expressed in stressed group compared to control group. Using a bioinformatics method, 135 protein-coding genes were predicted as the targets of significant differentially expressed miRNAs. Gene Ontology (GO) term and Ingenuity Pathway Analysis (IPA) mined that these target genes involved in some important pathways, which may have impact on meat quality and beef tenderness.
机译：miRNA是一类小的单链非编码RNA，它们通过与3'非翻译区结合来对目标基因进行转录后抑制。研究发现，miRNA参与许多代谢过程的调控。在这里，我们发现，急性应激后，安格斯牛的牛肉质量急剧多样化。通过进行miRNA微阵列分析，与对照组相比，应激组中有13种miRNA显着差异表达。使用生物信息学方法，预测了135个蛋白质编码基因为重要差异表达miRNA的靶标。基因本体论（GO）术语和独创性途径分析（IPA）认为这些靶基因参与了一些重要途径，可能会影响肉质和牛肉嫩度。

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