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首页> 外文期刊>Journal of Animal Science and Biotechnology >Dietary supplementation with a high dose of daidzein enhances the antioxidant capacity in swine muscle but experts pro-oxidant function in liver and fat tissues
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Dietary supplementation with a high dose of daidzein enhances the antioxidant capacity in swine muscle but experts pro-oxidant function in liver and fat tissues

机译：膳食补充高剂量的大豆苷元可以增强猪肌肉的抗氧化能力，但专家们在肝脏和脂肪组织中具有抗氧化功能

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Background Although isoflavones are natural dietary antioxidants, they may have toxicological effects. This study aimed to evaluate the redox system in tissues of finishing pigs by supplementation with high dose of daidzein (640 mg/kg). Results The supplementation of high dose of daidzein for 64 d increased the activity of superoxide dismutase and total antioxidant capacity in longissimus muscle but down-regulated the expression of reactive oxygen species (ROS)-producing enzyme NADPH oxidase-2 and cyclooxygenase-2. In contrast, high-level supplementation with daidzein exerted pro-oxidant changes in back fat, abdominal fat, liver, and plasma, as reflected by increased contents of malondialdehyde, a lipid peroxidation product, in these tissues. Furthermore, daidzein supplementation resulted in higher expression of ROS-producing enzymes, including NADPH oxidase-1 and cyclooxygenase-1 in liver, 5-lipoxygenase (5-LOX) in backfat and NADPH oxidase-2 both in abdominal fat and backfat. The supplementation of daidzein did not affect meat quality parameters in longissimus muscle, including marbling score, eye muscle areas, intramuscular fat, shear force, drip loss, pH and meat color. Conclusions This experiment suggests that dietary supplementation of finishing pigs with daidzein at a high dose level improves redox status in muscle but exerts pro-oxidant effect in liver and fat tissues.
机译：背景技术尽管异黄酮是天然的饮食抗氧化剂，但它们可能具有毒理作用。这项研究旨在通过补充高剂量的大豆苷元（640 mg / kg）来评估肥育猪组织中的氧化还原系统。结果大剂量黄豆苷元添加64 d可增加超长肌的超氧化物歧化酶活性和总抗氧化能力，但下调活性氧（ROS）产生酶NADPH oxidase-2和cyclooxygenase-2的表达。相反，高含量的大豆黄酮补充剂会在背部脂肪，腹部脂肪，肝脏和血浆中产生促氧化剂变化，这反映为这些组织中脂质过氧化产物丙二醛的含量增加。此外，黄豆苷元的添加导致肝脏中产生ROS的酶更高的表达，包括NADPH氧化酶-1和环加氧酶-1，背脂中的5-脂氧合酶（5-LOX）和腹脂和背脂中的NADPH氧化酶-2。补充大豆黄酮不会影响长背肌的肉质参数，包括大理石花纹，眼肌面积，肌内脂肪，剪切力，滴水损失，pH和肉色。结论该实验表明，高剂量的大豆黄酮对成年猪的日粮添加可改善肌肉的氧化还原状态，但对肝脏和脂肪组织具有促氧化作用。

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