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首页> 外文期刊>Journal of Anaesthesiology Clinical Pharmacology >Postoperative analgesia with epidural opioids after cesarean section: Comparison of sufentanil, morphine and sufentanil-morphine combination
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Postoperative analgesia with epidural opioids after cesarean section: Comparison of sufentanil, morphine and sufentanil-morphine combination

机译：剖宫产术后硬膜外阿片类药物的术后镇痛：舒芬太尼，吗啡和舒芬太尼-吗啡联合用药的比较

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Background: Epidural analgesia with opioid provides good control of postoperative pain in cesarean section, thereby improving the mother's ability to mobilize and interact with her newborn infant. Aim: The aim of this study is to evaluate and compare the analgesic actions and side effects of epidural analgesia with sufentanil, morphine or combination of the two after cesarean section. Materials and Methods: 60 women undergoing elective cesarean section were allocated into three groups of 20 each in a randomized blinded fashion. Epidural analgesia was administered with sufentanil 50 mcg in Group S; morphine 4 mg in Group M; and, a combination of sufentanil 25 mcg and morphine 2 mg was used in Group SM. Analgesic efficacy in terms of onset of action and duration of analgesia was assessed by using the Visual Analog Scale (0 to 10 cm) for 24 hours. Number of opioid doses needed in 24 hours was noted. Side effects like respiratory depression /excessive sedation, pruritus and nausea were recorded. Results: Onset of action were at 7.6 ± 1.5 minutes in group S, 67.6 ± 1.5 minutes in group M and 12.2 ± 2.6 minutes in group SM. Duration of analgesia was longer in group M 17.5 ± 1.9 hours and SM 13.8 ± 1.6 hours than in group S 5.2 ± 1.2 hours. More doses of analgesia were required in group S compared to group M and SM. Side effects were comparable in the three groups. Conclusion: Epidural administration of a combination of sufentanil and morphine offered the advantage of faster onset of action and longer duration of analgesia as compared to the two drugs administered alone.
机译：背景：阿片类药物的硬膜外镇痛可以很好地控制剖宫产术后的疼痛，从而提高母亲动员和与新生婴儿互动的能力。目的：本研究的目的是评估和比较剖宫产术后使用舒芬太尼，吗啡或两者的组合对硬膜外镇痛的镇痛作用和副作用。材料和方法：将60例行选择性剖宫产的妇女随机分为三组，每组20人。 S组给予舒芬太尼50 mcg进行硬膜外镇痛。 M组吗啡4 mg; SM组使用舒芬太尼25 mcg和吗啡2 mg的组合。通过使用视觉模拟量表（0至10 cm）评估24小时的镇痛效果，包括起效时间和镇痛持续时间。记录了24小时内所需的阿片类药物剂量的数量。记录有呼吸抑制/过度镇静，瘙痒和恶心等副作用。结果：S组的起效时间为7.6±1.5分钟，M组为67.6±1.5分钟，SM组为12.2±2.6分钟。 M组17.5±1.9小时和SM 13.8±1.6小时镇痛时间比S组5.2±1.2小时更长。与M和SM组相比，S组需要更多的镇痛剂量。三组的副作用相当。结论：与单独使用两种药物相比，硬膜外给药舒芬太尼和吗啡的组合具有起效快，镇痛时间长的优点。

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