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Body Mass and Fat Mass in Refractory Asthma: An Observational 1 Year Follow-Up Study

机译:难治性哮喘患者的体重和脂肪量:1年观察性随访研究

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Background. Asthma and obesity are common; however the impact of obesity upon asthma remains uncertain. Objectives. To assess relationships between obesity and fat mass with airway inflammation, lung function, and disease control in patients with refractory asthma. Methods. 151 refractory asthma patients were characterised for measures of airway inflammation, lung function, Juniper asthma control questionnaire (JACQ), body mass index (BMI), and fat mass index (FMI) derived from dual energy X-ray absorptiometry. Patients were reassessed over 12 months. Results. 74% of patients had an elevated BMI. BMI and FMI correlated (, ). FMI and JACQ correlated in men (, ). After 12 months 23% lost weight. Weight change over 12 months correlated with FEV1 change (, ), but not with change in JACQ or exacerbations. Conclusion. Increased fat mass is common in refractory asthma and is associated with asthma symptom control in men. Loss of weight is associated with improvement in lung function in refractory asthma.
机译:背景。哮喘和肥胖很常见;然而,肥胖对哮喘的影响尚不确定。目标。评估难治性哮喘患者的肥胖和脂肪量与气道炎症,肺功能和疾病控制之间的关系。方法。 151名难治性哮喘患者的特征在于通过双能X线吸收法得出的气道炎症,肺功能,瞻博哮喘控制问卷(JACQ),体重指数(BMI)和脂肪体重指数(FMI)。在12个月内对患者进行了重新评估。结果。 74%的患者BMI升高。 BMI和FMI相关(,)。男性的FMI和JACQ相关(,)。 12个月后,体重减轻了23%。 12个月内体重的变化与FEV1的变化(,)相关,但与JACQ的变化或加重无关。结论。脂肪量增加在难治性哮喘中很常见,并且与男性的哮喘症状控制有关。体重减轻与难治性哮喘的肺功能改善有关。

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