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首页> 外文期刊>Journal of Allergy >X-Ray Contrast Media Mechanisms in the Release of Mast Cell Contents: Understanding These Leads to a Treatment for Allergies
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X-Ray Contrast Media Mechanisms in the Release of Mast Cell Contents: Understanding These Leads to a Treatment for Allergies

机译：肥大细胞内含物释放中的X射线对比介质机制：了解这些因素可导致过敏治疗

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摘要

A long history of searching for the etiology of X-ray contrast material (CM) reactions has led to the understanding that the CM do not produce anti-CM antigens. Since CM reactions are anaphylactoid in nature, however, a source for mast cell activation was sought. This resulted in the finding that concentrated CM could suppress mast cell activation by attachment to the Fc portion of IgE and IgG. This is presumed to be a steric hindrance effect. In a study of the effects of CM on BP and a study of the effects of CM in sensitized rats, it was concluded that less concentrated CM activated mast cells and that this mechanism was best explained by bridging of adjacent IgE molecules via attachment to their Fc segments. The mast cell release of heparin activating the contact system, as well as the release of histamine, is believed to be responsible for CM reactions and allergic diatheses.
机译：寻找X射线对比材料（CM）反应的病因的悠久历史导致人们认识到CM不会产生抗CM抗原。然而，由于CM反应本质上是类过敏体，因此寻求肥大细胞活化的来源。这导致发现浓缩的CM可以通过附着于IgE和IgG的Fc部分来抑制肥大细胞活化。据推测这是位阻效应。在研究CM对BP的影响以及研究CM对致敏大鼠的影响时，得出的结论是，浓度较低的CM激活的肥大细胞，并且最好的解释是通过将相邻的IgE分子通过附着在其Fc上来桥接段。据信激活接触系统的肝素肥大细胞释放以及组胺的释放是造成CM反应和过敏性疾病的原因。

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