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首页> 外文期刊>Journal of Allergy >A Case of Severe Bronchial Asthma Controlled with Tacrolimus
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A Case of Severe Bronchial Asthma Controlled with Tacrolimus

机译：他克莫司控制的严重支气管哮喘一例

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Background. The control of severe bronchial asthma, such as corticosteroid-resistant asthma, is difficult. It is also possible that immunosuppressive agents would be effective for bronchial asthma. Case Summary. A 55-year-old Japanese female presented with severe bronchial asthma controlled with tacrolimus. She had been diagnosed with bronchial asthma during childhood. Her asthma worsened, and a chest radiograph showed atelectasis of the left lung. Bronchoscopy revealed the left main bronchus to be obstructed with viscous sputum consisting of 82% neutrophils and no eosinophils. The atelectasis did not improve with corticosteroid treatment, but was ameliorated by administration of tacrolimus. Discussion. This patient had severe asthma due to neutrophilic inflammation of the airways. Tacrolimus is effective for treating severe asthma, for example, in corticosteroid-resistant cases.
机译：背景。难以控制严重的支气管哮喘，例如耐糖皮质激素的哮喘。免疫抑制剂也可能对支气管哮喘有效。案例摘要。一名55岁的日本女性患有他克莫司控制的严重支气管哮喘。她在儿童时期被诊断出患有支气管哮喘。她的哮喘恶化，胸部X光片显示左肺不张。支气管镜检查发现左主支气管被粘稠的痰液阻塞，该痰液由82％的中性粒细胞组成，无嗜酸性粒细胞。皮质类固醇激素治疗后肺不张并没有改善，但他克莫司的使用改善了肺不张。讨论。该患者由于气道嗜中性炎症而患有严重的哮喘。他克莫司可有效治疗重度哮喘，例如在对皮质类固醇耐药的病例中。

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